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Immunotherapy has emerged as one of the most promising approaches for the treatment of cancer. T cells (T lymphocytes), the armed forces of our immune system, constantly look for foreign antigens and must discriminate abnormal (cancer or infected cells) from normal cells. Genetically modifying T cells with Chimeric Antigen Receptors (CAR)s is the most pursued approach to generate tumor-specific T cells. CAR-T cells targeting tumor-associated antigens can be infused into patients and attack the tumor.
ProMab Biotechnologies Custom Chimeric Antigen Receptor Cell Engineering: A complete service, from antigen to clinically relevant solution.
ProMab Biotechnologies (PMB) has developed many CAR-T products based on nearly 20 years' experience on hybridomas, monoclonal antibodies (rabbit, mouse, and human), recombinant proteins, and cancer stem cells. PMB's new custom CAR-T service is designed to take advantage of the astonishing clinical breakthroughs of CAR-T cells against various hematological malignancies.
PMB can construct CARs based on your antibody sequence or can generate a mouse or fully human single-chain variable fragment (scFv) for the CARs. PMB has generated more than 30 types of CAR-T and CAR-NK cells targeting different tumor cells and cell lines expressing tumor-specific antigens.
These CAR-T cells can be used with immunological modulators, tumor microenviroment invaders, or checkpoint inhibitors. In addition, PMB has developed sensitive real-time cytotoxicity assays (RTCA) for CAR-T cell validation in vitro and ex vivo. ProMab has also developed in vivo NSG/ NOG xenograft models to test CAR-T cell anti-cancer activity in hematological and solid cancers.
Here we outline 8 components to a successful CAR platform:
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