Custom Gamma Delta T Cell Development

Having developed over 60 types of CAR-T/NK cells and target cells, we were able to leverage our experience to develop gamma delta T cells. As the most experienced CRO in the CAR-T cell industry, you can rely on us to deliver high-level custom gamma delta T cell engineering, providing you with an interesting new immunotherapy tool to accelerate your cancer research.

  • Experiment with the advantages gamma delta T cells have over alpha beta T cells.
  • Explore new immunotherapy options for cancer treatment.
  • Benefit from innate and adaptive immune cell properties.
  • Rely on expert advice and guidance from our 5 years of developing custom cell lines.

A robust and potent tool

With their innate and adaptive properties, gamma delta T cells exhibit better potency against more difficult tumors than regular alpha beta T cells. Shown in several studies to robustly kill a wide range of solid and hematopoietic tumor cells, gamma T cells have an MHC-independent nature, meaning they carry less risk of graph vs. host disease (GVHD). Gamma delta T cells can also act as APC to prime T cell activity and promote class switching in B cells, further augmenting the tumor prognosis.

CUSTOM VECTOR DESIGN

TRANSDUCTION OF GAMMA DELTA T CELLS 

IN VITRO AND IN VIVO TESTING ASSAYS

 

Streamlining Your Preclinical and Clinical Development

With our in-house vivarium and 2 GMP manufacturing facilities, we are fully equipped to offer high-quality preclinical and clinical development studies. Whatever your CAR gamma delta T cell project needs, we have the discovery and development service to suit you. 

We have several options for how to engage with our development services, including licensing and partnering. Contact us to find out how we can tailor our services to your CAR gamma delta T cell project today.

 

Discovery Services Timelines

Make use of our comprehensive discovery services to accelerate your research timelines. With our end-to-end in vitro and in vivo offerings, all contained within a single organization, the process is streamlined for you saving you time and money. Whatever your starting point, our discovery and development services can be tailored to suit the needs of your project.

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Develop Antibodies

Create mouse, rabbit, and human monoclonal antibodies using our validated antibody design and development platforms.

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Package Vectors

Innovate your cancer immunotherapies by packaging novel co-expression constructs and any generation of CAR domain into your vectors.

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Scale Production

Expand your research horizons with scalable CAR gamma delta T cell production from our GMP manufacturing facilities.

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Ensure Quality

Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with years of CAR immune cell experience.

Service plans and prices

ProMab can help you advance your ideas and technologies with our two configurable service plans:

Plan A

Generate the entire construct from a mouse monoclonal antibody or fully human single-chain variable antibody fragment (scFv) from our existing library.

DEVELOPMENT STAGE DESCRIPTION Price
Phase I (optional) Immunization of Balb/C mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly presented antigen. $6,995
Phase II (optional) Sequencing of the antibody's heavy and light chains. $1,800
Phase III Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Generation of lentivirus viral particles. $10,000
Phase IV Gamma delta T cell activation, lentiviral transduction, and Gamma Delta CAR-T expansion. $10,000
Phase V RTCA/Cytokine assays to determine cell cytotoxicity and functionality $10,000

Plan B

Construct a CAR based on your antibody sequence.

DEVELOPMENT STAGE DESCRIPTION Price
Phase III

Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Generation of lentivirus viral particles.

$10,000
Phase IV Gamma delta T cell activation, lentiviral transduction, and Gamma Delta CAR-T expansion. $10,000
Phase V RTCA/Cytokine assays to determine cell cytotoxicity and functionality $10,000
Phase VI NSG/NOG xenograft model Starting at $20,000

Leverage a new immunotherapy tool today

We’ll take care of your gamma delta T-cell development so that you can focus on insights and innovations. Together, we can change the way the world treats cancer.

5,000+

monoclonal antibodies generated

50+

filed patents

500+

CAR-T projects finished

4

Phase 2 clinical trials started

Featured Publications

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells.
Generation of CAR-T Cells for Cancer Immunotherapy.
CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth.

FAQs

What are CAR gamma delta T cells?

Why choose CAR gamma delta T cells over CAR-T cells?

What models do ProMab have to support my CAR Gamma delta T cell development?

Related Services

Custom Antibody Generation

Advance your antibody R&D with our well-established services designed by specialists with over 2 decades of experience generating highly specific and potent monoclonal antibodies.

Protein Expression

Obtain the protein or peptide of interest for your functional assays, target validation, or antibody development, guided by ProMab’s 22+ years of experience in protein expression and purification services.

Cell Line Engineering

Whether you need ‘ready-made’ or custom cell line development services, our experienced team is here to aid you in CAR-T, CAR-NK, CAR-Macrophage, engineered cell lines, and in vitro validation.