Custom Gamma Delta T Cell Development
Having developed over 60 types of CAR-T/NK cells and target cells, we were able to leverage our experience to develop gamma delta T cells. As the most experienced CRO in the CAR-T cell industry, you can rely on us to deliver high-level custom gamma delta T cell engineering, providing you with an interesting new immunotherapy tool to accelerate your cancer research.
- Experiment with the advantages gamma delta T cells have over alpha beta T cells.
- Explore new immunotherapy options for cancer treatment.
- Benefit from innate and adaptive immune cell properties.
- Rely on expert advice and guidance from our 5 years of developing custom cell lines.
A robust and potent tool
With their innate and adaptive properties, gamma delta T cells exhibit better potency against more difficult tumors than regular alpha beta T cells. Shown in several studies to robustly kill a wide range of solid and hematopoietic tumor cells, gamma T cells have an MHC-independent nature, meaning they carry less risk of graph vs. host disease (GVHD). Gamma delta T cells can also act as APC to prime T cell activity and promote class switching in B cells, further augmenting the tumor prognosis.
|
CUSTOM VECTOR DESIGN |
TRANSDUCTION OF GAMMA DELTA T CELLS |
IN VITRO AND IN VIVO TESTING ASSAYS |
Streamlining Your Preclinical and Clinical Development
With our in-house vivarium and 2 GMP manufacturing facilities, we are fully equipped to offer high-quality preclinical and clinical development studies. Whatever your CAR gamma delta T cell project needs, we have the discovery and development service to suit you.
We have several options for how to engage with our development services, including licensing and partnering. Contact us to find out how we can tailor our services to your CAR gamma delta T cell project today.
Discovery Services Timelines
Make use of our comprehensive discovery services to accelerate your research timelines. With our end-to-end in vitro and in vivo offerings, all contained within a single organization, the process is streamlined for you saving you time and money. Whatever your starting point, our discovery and development services can be tailored to suit the needs of your project.
Develop Antibodies
Create mouse, rabbit, and human monoclonal antibodies using our validated antibody design and development platforms.
Package Vectors
Innovate your cancer immunotherapies by packaging novel co-expression constructs and any generation of CAR domain into your vectors.
Scale Production
Expand your research horizons with scalable CAR gamma delta T cell production from our GMP manufacturing facilities.
Ensure Quality
Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with years of CAR immune cell experience.
Service plans and prices
ProMab can help you advance your ideas and technologies with our two configurable service plans:
Plan A
Generate the entire construct from a mouse monoclonal antibody or fully human single-chain variable antibody fragment (scFv) from our existing library.
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase I (optional) | Immunization of Balb/C mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly presented antigen. | $6,995 |
| Phase II (optional) | Sequencing of the antibody's heavy and light chains. | $1,800 |
| Phase III | Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Generation of lentivirus viral particles. | $10,000 |
| Phase IV | Gamma delta T cell activation, lentiviral transduction, and Gamma Delta CAR-T expansion. | $10,000 |
| Phase V | RTCA/Cytokine assays to determine cell cytotoxicity and functionality | $10,000 |
Plan B
Construct a CAR based on your antibody sequence.
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase III |
Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Generation of lentivirus viral particles. |
$10,000 |
| Phase IV | Gamma delta T cell activation, lentiviral transduction, and Gamma Delta CAR-T expansion. | $10,000 |
| Phase V | RTCA/Cytokine assays to determine cell cytotoxicity and functionality | $10,000 |
| Phase VI | NSG/NOG xenograft model | Starting at $20,000 |
Leverage a new immunotherapy tool today
We’ll take care of your gamma delta T-cell development so that you can focus on insights and innovations. Together, we can change the way the world treats cancer.
5,000+
monoclonal antibodies generated
50+
filed patents
500+
CAR-T projects finished
4
Phase 2 clinical trials started
Featured Publications
FAQs
What are CAR gamma delta T cells?
Why choose CAR gamma delta T cells over CAR-T cells?
What models do ProMab have to support my CAR Gamma delta T cell development?
Related Services
Custom Antibody Generation
Advance your antibody R&D with our well-established services designed by specialists with over 2 decades of experience generating highly specific and potent monoclonal antibodies.
Cell Line Engineering
Whether you need ‘ready-made’ or custom cell line development services, our experienced team is here to aid you in CAR-T, CAR-NK, CAR-Macrophage, engineered cell lines, and in vitro validation.
Super CAR-NK
This innovative service represents a significant leap forward from traditional CAR-NK therapies. At its core, Super CAR-NK is designed to enhance immunotherapeutic efficacy, providing an unprecedented level of target cell elimination.