Animal Supply and Model

ProMab Biotechnologies offers a comprehensive range of animal supply and animal modeling services designed to empower researchers and scientists in advancing their research. Our state-of-the-art facilities and ethical standards ensure that you receive the highest quality of service and support for your scientific endeavors. Trust in ProMab to be your partner in innovation, providing reliable solutions to meet the complex demands of modern research.

Animal Supply

Discover the future of scientific research and development with our premier selection of laboratory mice. By choosing our mice for your animal study models, you're embracing reliability, reproducibility, and exceptional quality for groundbreaking discoveries, all while adhering to the highest standards of ethical treatment. Partner with us to propel your research projects forward with confidence and unlock new possibilities in the world of science.

Mice Types
BRG Mice
C-NKG-H2-Ab1 KO Mice
NKG
C-NKG B2m KO
Rag1 KO
Rag2 KO
Tcra KO
B6J-Ighm Ighd-DKO
BALB/c-Ighm Ighd-DKO
B6-Ighm KO
BALB/c-Ighm KO
B6-Ighj KO
BALB/c-Ighj KO

 

Animal Study Models

Patient Derived Xenograft for In Vivo Pharmacology Studies

Patient-Derived Xenografts (PDX) are advanced cancer models where patient tumor cells are implanted into specially prepared mice, creating a more human-like environment for studying cancer progression, drug efficacy, and resistance. These models offer crucial insights into how therapies will perform in humans, aiding in drug discovery by improving target validation, candidate selection, and identification of patient populations and biomarkers.

Cell-Line Derived Xenograft Tumor Models

Derived from a diverse range of tumor cell lines, these models excel in adaptability, swiftly forming tumors in immunodeficient mice through various implantation methods. Ideal for preclinical testing, they pave the way for groundbreaking evaluations of drug efficacy, pharmacodynamics, and combination therapies. Despite emerging trends, CDX models stand out for their remarkable consistency and reliability, making them an indispensable tool in the quest for innovative cancer therapies. Dive into the future of cancer research with our CDX models, where precision meets progress.

CDX tumor model

Imaging: Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), Magnetic Resonance Imaging (MRI), NIR-II and small animal molecular imaging.

Animal Study Image 001

Animal Study Image 002

Bioluminescence Imaging

Bioluminescence Imaging

We have several luciferase­positive cell lines that can be analyzed using ivis imaging systems together with your CAR-T cells:

4T1-luc+ HT29-luc+ U87-luc+-GFP+ A549-luc+
Raji-luc+-GFP+ PAN CO2-Luc+ PC3M-luc+ 816/F10-luc+
HCT116-luc+
  • bpIndustry standard in vivo imaging system.
  • bpScientific grade 1 CCD camera, back­ thinned, back-illuminated, cooled to -70C.
  • bpLight tight imaging chamber with a high collection lens, 50mm, f/0.95-f/8.
  • bpIntegrated isoflurane gas anesthesia system
U87-luc Glioma

U87Luc Glioma

Female nu/nu mice with orthotopic U87-
luc. Day 6 Post Implant of lx106 cells

The Imaging System Detects Luciferase-Positive Cells in Mice Xenografts:

The IVIS imaging system detects tumors in orthotopic intracranial U87-luc cell injection with lucifearin as a substrate. The quantification is done in photons/sec units and tumor growth curves are gene rated. Different Lu cite rase-positive cell lines are available for CAR-T cell efficacy study. In addition, customized luciferase-positive cell lines can be generated for testing efficacy CAR-T cell