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CAR-T cells
CAR-T/CAR-NK Products
Promab Biotechnologies has generated different CAR-T/CAR-NK products such as: CAR-T cells are T cells either from the group of donors or from individual donor transduced with CAR (Chimeric antigen receptor)-lentivirus. The CAR-T cells can target different tumor antigens such CD19, CD133, Her-2, EGFR, VEGFR-2, mesothelin that are highly over-expressed in tumors. The CAR-T cells can express inducible caspase-9 or other suicide gene to induce CAR-T cell killing for increased safety in case this construct in future will be proposed to use in clinical trials. All CAR-T cells are checked for transduction efficiency (Fab Ab by Flow cytometry), cell killing activity: IL-2, IFN-gamma assay; and Real time cytotoxicity activity). All CAR-T cells have negative mock controls: lentivirus-transduced CAR-T cells, no ScFv-transduced CAR-T cells and non transduced T cells.
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Promab Biotechnologies has generated the following CAR-T products:CAR-T Cells
| Catalog # | Description | Cell Number | Price | DataSheet |
| PM-CAR1000-1M | 'Mock' ScFv Control | 1x10 6 /vial | $1,000 |  |
| PM-CAR1001-1M | CD19scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1002-1M | CD19scFv-4-1BB-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1003-1M | CD19scFv-CD28-4-1BB-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1004-1M | CD19scFv-CD28-4-1BB | 1x10 6 /vial | $1,000 | |
| PM-CAR1005-1M | CD19scFv-4-1BB-CD3z-GFPĀ | 1x10 6 /vial | $1,000 | |
| PM-CAR1006-1M | iCas9-T2A-antiCD19scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,200 | |
| PM-CAR1007-1M | CD19scFv-FLAG-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1008-1M | no scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,200 | |
| PM-CAR1009-1M | CD19scFv-CD28 | 1x10 6 /vial | 1,000 | |
| PM-CAR1010-1M | iCas9 HA-T2A-antiCD19scFv-CD28-CD3Ī¶āGGGS-FLAG | 1x10 6 /vial | $1,000 | |
| PM-CAR1011-1M | Mesothelin scFv-CD28-CD3Ī¶ (2nd) | 1x10 6 /vial | $1,000 | |
| PM-CAR1012-1M | Mesothelin scFv-CD28-4-1BB-CD3Ī¶ (3rd) | 1x10 6 /vial | $1,000 | |
| PM-CAR1013-1M | Mesothelin scFv-4-1BB-CD3Ī¶ (2nd) | 1x10 6 /vial | $1,000 | |
| PM-CAR1014-1M | Mesothelin scFv-FLAG-CD28-CD3Ī¶Ā | 1x10 6 /vial | $1,000 | |
| PM-CAR1015-1M | Mesothelin scFv-FLAG-4-1BB-CD3Ī¶ (2nd) | 1x10 6 /vial | $1,000 | |
| PM-CAR1016-1M | VEGFR2scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1017-1M | GPC3 scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1018-1M | CD133 scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1019-1M | EpCAM1 scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1020-1M | EpCAM*scFv-CD28-CD3Ī¶ * NheI restriction site introduced, N-terminal of scFV (amino acids: AS) | 1x10 6 /vial | $1,000 | |
| PM-CAR1021-1M | EGFRscFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1022-1M | EGFRscFv-4-1BB-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1024-1M | Her2 scFv-CD28-CD3Ī¶ | 1x10 6 /vial | $1,000 | |
| PM-CAR1025-1M | EGFR-TM28-CD3zeta-GITR | 1x10 6 /vial | $1,000 | |
| PM-CAR1026-1M | CD33-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1027-1M | CD38-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1028-1M | CD138-Beam 1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1029-1M | CD22-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1030-1M | CD22-CD8TM-41BB-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1031-1M | BCMA-4-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1032-1M | CD4-Beam 1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1033-1M | Humanized BCMA-2-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1034-1M | Mouse ROR-1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1035-1M | CD19-CD22-41BB-CD3 (stanford published) | 1x10 6 /vial | $1,000 | |
| PM-CAR1036-1M | Humanized CEA-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1037-1M | BCMA-4-TM8-41BB-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1038-1M | NGFR-TM28-CD28-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1039-1M | MCAM-TM28-CD28-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1040-1M | CD47-TM28-CD28-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1041-1M | Humanized CD47-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1042-1M | Humanized 1-CD19-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1043-1M | Humanized 1 CD19-Beam 1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1044-1M | Human ROR1-TM28-41BB-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1045-1M | PDL-1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1046-1M | CD123-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1047-1M | CD22-Beam2-TM28-Cd28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1048-1M | CD19Beam2-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1049-1M | CD19-CD22-41BB-CD3-T2A-tEGFR (Cetuximab sucicide switch | 1x10 6 /vial | $1,000 | |
| PM-CAR1050-1M | CD19-CD22-41BB-CD3-T2A-RQR8 (Ritiximab suicide switch) | 1x10 6 /vial | $1,000 | |
| PM-CAR1051-1M | CS1-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1052-1M | CD37-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1053-1M | CD37-TM28-41BB-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1054-1M | CD19-TM-28-GITR-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1055-1M | CD19-TM-8-GITR-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1056-1M | CD33-Beam2-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1057-1M | CS1p-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1058-1M | B7H4-TM28-CD28-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1059-1M | CD24-TM28-CD28-CD3 zeta | 1x10 6 /vial | $1,000 | |
| PM-CAR1060-1M | Mesothelin-TM28-CD28-41BB-CD3 | 1x10 6 /vial | $1,000 | |
| PM-CAR1061-1M | 3x Beam 2-TM28-CD28-CD3 (Mock)Ā | 1x10Ā 6Ā /vial | $1,000 | Ā |
Non-Transduced T Cells
The non-transduced T cells are available in frozen vials that can be activated and expanded with CD28/CD3 beads and used as a negative control in all assays with CAR-T cells. Promab Biotechnologies has non transduced T cells from different donor that can be used in the assay to test individual differences among different donors.
| Catalog # | Description | Cell Number | Price | DataSheet |
| PM-CAR2003 | Non-transduced T-cells, healthy donor | 1x10 6 /vial | $500 | |
| PM-CAR2004 | Non-transduced T-cells, ALL | 1x106/vial | $500 | |
| PM-CAR2005 | Non-transduced T-cells, CLL | 1x106/vial | $500 | |
| PM-CAR2006 | Non-transduced T-cells, ALL | 1x106/vial | $500 | |
| PM-CAR2007 | Non-transduced T cells CD4+ | 1x106/vial | $500 | |
| PM-CAR2008 | Non-transduced T cells CD8+ | 1x106/vial | $500 | |
| PM-CAR2009 | Non-transduced T CD4+ CM cellsĀ | 1x106/vial | $500 | |
| PM-CAR2010 | Non-transduced CD4+ T EM cellsĀ | 1x106/vial | $500 | |
| PM-CAR2011 | Non-transduce T naĆÆve | 1x106/vial | $500 | |
| PM-CAR2012 | Non-transduce T SCM | 1x106/vial | $500 | |
Engineered CAR-T Target Cells
Promab Biotechnologies has developed several target cell lines to be used in cytotoxicity assays with CAR-T effector cells. These cells express tumor antigen that is overexpressed in malignant cells, can have GFP or luciferase for in vivo studies.
| Catalog # | Description | Marker | Cell Number | Price | Datasheet |
| PM-Raji-GFP | Raji-GFP stable expression | CD19+, eGFP | 1x106/vial | $6,000 | |
| PM-Jurkat-GFP | Jurkat-GFP stable expression | CD19-, eGFP | 1x106/vial | $6,000 | |
| PM-K562-GFP | K562-GFP stable expression | CD19-, eGFP | 1x106/vial | $6,000 | |
| PM-HELA-CD19 | HeLa-CD19 stable expression | CD19+ | 1x106/vial | $8,000 | |
| PM-CHO-CD19 | CHO-CD19 stable expression | CD19+ | 1x106/vial | $6,000 | |
| PM-CHO-CD47 | CHO-CD47 stable expression | CD47 | 1x106/vial | $8,000 | |
| PM-BxPC3-GFP+-LUC+ | BxPC3-GFP+-LUC+ stable expression | GFP, LUC | 1x106/vial | $8,000 | |
| PM-CHO-BCMA | CHO-BCMA stable expression | BCMA | 1x106/vial | $8,000 | |
| PM-CHO-CD22 | CHO-CD22 stable expression | CD22 | 1x106/vial | $8,000 | |
| PM-CHO-CS1 | CHO-CS1 stable expression | CS1 | 1x106/vial | $8,000 | |
| PM-RPMI8226-GFP+-LUC+ | RPMI8226-GFP+-LUC+Ā stable expression | GFP, LUC | 1x106/vial | $8,000 | |
| PM-H929-GFP+-LUC+ | GFP+-LUC+Ā stable expression | GFP, LUC | 1x106/vial | $8,000 | |
| PM-SKOV-3-GFP+-LUC+ | SKOV-3-GFP+-LUC+Ā stable expression | GFP,LUC | 1x106/vial | $8,000 | |
PBMC
| Catalog # | Description | Cell Number | Price | DataSheet |
| PM-CAR3000 | PBMC, ALL | 1x106/vial | $500 | |
| PM-CAR3001 | PBMC-CLL | 1x106/vial | $500 | |
| PM-CAR3002 | PBMC-NHL | 1x106/vial | $500 | |
Cell Media and Activation Beads
| Catalog # | Description | Volume/Unit | Price | DataSheet |
| PM-CAR2000 | CAR-T Cell Expansion Medium (human serum) | 500 ML | $899 | |
| PM-CAR2001 | CAR-T Cell Medium(Fetal Bovine Serum) | 500 ML | $599 | |
| PM-CAR2002-2ML | CD28/CD3 PM-T-Cell Activation/Expansion Beads | Ā 2 Ā ML | $499 | |
| PM-CAR2002-10ML | CD28/CD3 PM-T-Cell Activation/Expansion Beads | Ā 10 ML | $1,400 | |
Under Current Development
| Her-3(Erb-3) | Her-4(Erb-4) | CEA | EGFRviii | PSMA | CD20 |
| VEGFR-1 | VEGFR-3 | c-Met | Lewis A | ROR-1 | CD326 |
| CD133 | CD19 CAR+PD-1 siRNA | CD19+ TIGIT siRNA | BCMA-CS1 | BCMA-CD33 | NKG2d |
| MUC1 | PSCA | PSA | CA-125 (MUC16) |
Notch |