Promab Biotechnologies has generated CARs (chimeric antigen receptors) specific for a variety of target antigens, many of which are overexpressed on tumor cells. These target antigens include CD19, CD22, CD133, Her-2, EGFR, Mesothelin, and more (see Table, below). In addition, Promab has modified the CARs in a number of ways to increase their utility, including adding inducible caspase-9 as a safety switch; adding non-immunogenic tags to provide for CAR identification and selection; and using different costimulatory domains to modulate CAR functional responses.
Promab Biotechnologies uses high-titer lentivirus transduction to introduce the CARs into T cells, generating CAR-T cells. Promab has also generated CAR-NK cells and CAR-macrophages for a subset of CARs. The CAR-T cells are validated using multiple methods, including flow cytometry (to determine the CAR-T frequency and phenotype), real-time and end-point cytotoxicity assays, cytokine production and checkpoint protein upregulation.
For a negative control, Promab has generated a mock CAR which lacks the target-recognizing scFv domain but can be detected with the Beam-2 antibody. Promab also offers non-transduced T cells as another negative control.
Promab Biotechnologies has generated the following CAR-T products:
CAR-T Cells
Catalog # |
Description |
Cell Number |
Price |
DataSheet |
PM-CAR1000-1M |
Mock scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1001-1M |
CD19 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1002-1M |
CD19 scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1003-1M |
CD19 scFv-CD28-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1004-1M |
CD19 scFv-CD28-4-1BB |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1005-1M |
CD19scFv-TM-41BB-CD3z-T2A-GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1006-1M |
iCas9-T2A-antiCD19 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1007-1M |
CD19 scFv-FLAG-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1008-1M |
no scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1009-1M |
CD19 scFv-CD28 |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1010-1M |
iCas9 HA-T2A-antiCD19scFv-CD28-CD3ζ−GGGS-FLAG |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1011-1M |
Mesothelin scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1012-1M |
Mesothelin scFv-CD28-4-1BB-CD3ζ (3rd) |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1013-1M |
Mesothelin scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1014-1M |
Mesothelin scFv-FLAG-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1015-1M |
Mesothelin scFv-4-1BB-CD3ζ-FLAG |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1016-1M |
VEGFR2 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1017-1M |
GPC3 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1018-1M |
CD133 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1019-1M |
EpCAM1 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1020-1M |
EpCAM scFv-CD28-CD3ζ * NheI restriction site introduced, N-terminal of scFV (amino acids: AS) |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1021-1M |
EGFR scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1022-1M |
EGFR scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1023-1M |
EGFR scFv-TM28-GITR-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1024-1M |
Her2 scFv-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1025-1M |
EGFR scFv-TM28-CD3ζ-GITR |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1026-1M |
CD33 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1027-1M |
CD38 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1028-1M |
CD138 scFv-Beam1-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1029-1M |
CD22 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1030-1M |
CD22 scFv-TM8-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1031-1M |
BCMA-4-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1032-1M |
CD4 scFv-Beam1-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1033-1M |
Humanized BCMA-2 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1034-1M |
Mouse ROR-1 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1035-1M |
CD19 scFv-CD22 scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1036-1M |
Humanized CEA scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1037-1M |
BCMA-4 scFv-TM8-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1038-1M |
NGFR scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1039-1M |
MCAM scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1040-1M |
CD47 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1041-1M |
Humanized CD47 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1042-1M |
Humanized CD19 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1043-1M |
Humanized CD19 scFv-Beam1-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1044-1M |
Human ROR1 scFv-TM28-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1045-1M |
PDL-1 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1046-1M |
CD123 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1047-1M |
CD22 scFv-Beam2-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1048-1M |
CD19 scFv-Beam2-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1049-1M |
CD19 scFv-CD22 scFv-4-1BB-CD3-T2A-tEGFR (Suicide switch) |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1050-1M |
CD19 scFv-CD22 scFv-4-1BB-CD3-T2A-RQR8 (Ritiximab suicide switch) |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1051-1M |
BCMA-2 scFv-TM-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1052-1M |
CD37 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1053-1M |
CD37 scFv-TM28-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1054-1M |
CD19 scFv-TM28-GITR-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1055-1M |
CD19 scFv-TM8-GITR-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1056-1M |
CD33 scFv-Beam 2-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1057-1M |
CS1 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1058-1M |
B7H4 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1059-1M |
CD24 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1060-1M |
Mesothelin scFv-TM28-CD28-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1061-1M |
Beam2-TM28-CD28-CD3ζ (Mock) |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1062-1M |
CD20 scFv-TM28-CD28-CD3ζ |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1063-1M |
Her2 scFv-4-1BB-CD3ζ-EGFRt |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1064-1M |
Her2 scFv-4-1BB-CD3ζ-GFP |
1x10 6 /vial |
$1,200 |
 |
PM-CAR1065-1M |
c-MET scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1066-1M |
CD19 scFv-FLAG-CD28-CD3ζ-EGFRt |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1067-1M |
CD19 scFv-FLAG-4-1BB-CD3ζ-EGFRt |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1068-1M |
EpCAM scFv-TM-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1069-1M |
PSMA scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1070-1M |
Her2 scFv-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1071-1M |
CD19 scFv-4-1BB-CD3ζ-GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1072 |
EphA2scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1073 |
CD38scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1074 |
CD70scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1075 |
CD147scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1076 |
EpCAMscFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1077 |
CLDN18.2scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1078 |
FRalpha scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1079 |
⍺FPscFv-TM-4-1BB-CD3ζ |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1080 |
CD20scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1081 |
CD22scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1083 |
Her2scFv-TM-CD28-CD3z /// GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1084 |
Her2scFv-TM-CD28-CD3z /// tEGFR |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1085 |
GPC3scFv-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1086 |
3xTF-TM-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1087 |
CD19scFv-TF-CD28-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1088 |
CD19scFv-FLAG-CD28-4-1BB-CD3z /// GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1089 |
EGFRscFv-TM-4-1BB-CD3z /// GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1090 |
CD19 scFv-FLAG-4-1BB-CD3z /// GFP |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1091 |
PSCA scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1092 |
CLL-1 scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1093 |
CA-125 scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1094 |
GD2 scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
PM-CAR1095 |
Mucin-1 scFv-4-1BB-CD3z |
1x10 6 /vial |
$1,200 |
Coming Soon |
CAR Macrophage Cells
Catalog # |
Description |
Cell Number |
Price |
DataSheet |
PM-CARMA01 |
CD19 scFv-Flag CAR THP-1 Cells |
1x106 /vial |
$6,000 |
 |
PM-CARMA02 |
Mesothelin scFv CAR THP-1 Cells |
1x106/vial |
$6,000 |
 |
Non-Transduced T Cells
The non-transduced T cells are available in frozen vials that can be activated and expanded with CD28/CD3 beads and used as a negative control in all assays with CAR-T cells. Promab Biotechnologies has non transduced T cells from different donor that can be used in the assay to test individual differences among different donors.
Catalog # |
Description |
Cell Number |
Price |
DataSheet |
PM-CAR2003 |
Non-transduced T cells, healthy donor |
1x106 /vial |
$550 |
 |
PM-CAR2004 |
Non-transduced T cells, ALL |
1x106/vial |
$550 |
 |
PM-CAR2005 |
Non-transduced T cells, CLL |
1x106/vial |
$550 |
 |
PM-CAR2006 |
Non-transduced T cells, NHL |
1x106/vial |
$550 |
 |
PM-CAR2007 |
Non-transduced T cells CD4+ T cells |
1x106/vial |
$1,200 |
 |
PM-CAR2008 |
Non-transduced T cells CD8+ T cells |
1x106/vial |
$1,200 |
 |
PM-CAR2009 |
Non-transduced T CD4+ Tcm cells |
1x106/vial |
$1,200 |
 |
PM-CAR2010 |
Non-transduced CD4+ Tem cells |
1x106/vial |
$1,200 |
 |
PM-CAR2011 |
Non-transduced Tnaïve cells |
1x106/vial |
$1,200 |
 |
PM-CAR2012 |
Non-transduced Tcm cells |
1x106/vial |
$1,200 |
 |
PM-CAR2014 |
Trasnduced GFP+ T cells |
1x106/vial |
$1,200 |
 |
Non-Transduced Macrophages
Catalog # |
Description |
Cell Number |
Price |
DataSheet |
PM-CAR2013 |
Non-transduced Macrophage Cells |
1x106/vial |
$550 |
 |
Engineered CAR-T Target Cells
ProMab has developed several target cell lines to be used in cytotoxicity assays with CAR-T effector cells. These cells express specific tumor antigens that are overexpressed in malignant cells, or can have GFP or luciferase for in vivo studies, or knockout target antigens by CRISPR.
Catalog # |
Description |
Marker |
Cell Number |
Price |
Datasheet |
PM-Raji-GFP |
Raji-GFP-LUC stable expression |
GFP+, LUC+, CD19+ |
1x106/vial |
$6,000 |
 |
PM-Jurkat-GFP |
Jurkat-GFP-LUC stable expression |
GFP+, LUC+, CD19- |
1x106/vial |
$6,000 |
 |
PM-K562-GFP |
K562-GFP-LUC stable expression |
GFP+, LUC+, CD19- |
1x106/vial |
$6,000 |
 |
PM-BxPC3-GFP-LUC |
BxPC3-GFP-LUC stable expression |
GFP+, LUC+ |
1x106/vial |
$6,000 |
 |
PM-RPMI8226-GFP-LUC |
RPMI8226-GFP-LUC stable expression |
GFP+, LUC+ |
1x106/vial |
$6,000 |
 |
PM-H929-GFP-LUC |
H929-GFP-LUC stable expression |
GFP+, LUC+ |
1x106/vial |
$6,000 |
 |
PM-SKOV-3-GFP-LUC |
SKOV3-GFP-LUC stable expression |
GFP+, LUC+ |
1x106/vial |
$6,000 |
 |
PM-CD19-HELA |
CD19-HeLa stable expression |
CD19+ |
1x106/vial |
$6,000 |
 |
PM-BCMA-HELA-GFP |
BCMA-HeLa-GFP stable expression |
GFP+ |
1x106/vial |
$6,000 |
 |
PM-BCMA-CHO |
BCMA-CHO stable expression |
BCMA+ |
1x106/vial |
$8,000 |
 |
PM-CS1-HELA-GFP |
CS1-HeLa-GFP stable expression |
GFP+ |
1x106/vial |
$6,000 |
 |
PM-CD19-CHO |
CD19-CHO stable expression |
CD19+ |
1x106/vial |
$8,000 |
 |
PM-CD22-CHO |
CD22-CHO stable expression |
CD22+ |
1x106/vial |
$8,000 |
 |
PM-CD37-CHO |
CD37-CHO stable expression |
CD37+ |
1x106/vial |
$8,000 |
 |
PM-CD47-CHO |
CD47-CHO stable expression |
CD47+ |
1x106/vial |
$8,000 |
 |
PM-CS1-CHO |
CS1-CHO stable expression |
CS1+ |
1x106/vial |
$8,000 |
 |
PM-BCMA-K562-GFP |
BCMA-K562-GFP stable expression |
GFP+ |
1x106/vial |
$6,000 |
 |
PM-SKOV3-ROR1-KO |
ROR1 knockout SKOV3 cell line |
ROR1- |
1x106/vial |
$6,000 |
 |
PM-HeLa-ROR1-KO |
ROR1 knockout HeLa cell line |
ROR1- |
1x106/vial |
$6,000 |
 |
Cell Media and Activation Beads
Under Current Development
Her-3(Erb-3) |
Her-4(Erb-4) |
CEA |
EGFRviii |
PSMA |
CD20 |
VEGFR-1 |
VEGFR-3 |
c-Met |
Lewis A |
ROR-1 |
CD326 |
CD133 |
CD19 CAR+PD-1 siRNA |
CD19+ TIGIT siRNA |
BCMA-CS1 |
BCMA-CD33 |
NKG2d |
MUC1 |
PSCA |
PSA |
CA-125 (MUC16) |
Notch |
FLT-3 |
CAR Detection Probes
Catalog # |
Description |
Unit Size |
Price |
DataSheet |
PM-AB001 |
Beam1 Antibody |
100ul, 1 vial |
$449 |
 |
PM-AB002 |
Beam2 Antibody |
100ul, 1 vial |
$449 |
 |
PM-AB003 |
BCMA Biotinylated Protein |
50ug, 1 vial |
$449 |
 |
PM-AB004 |
Mesothelin Biotinylated Protein |
50ug, 1 vial |
$449 |
 |