Custom CAR-Macrophage Cell Development

As the most experienced CRO in the CAR-T cell industry, having developed over 60 types of CAR-T/NK cells and target cells, we have applied our extensive knowledge of CAR-technology to developing CAR-macrophages. Partnering with our custom service allows you to design CAR-macrophages for your research, leveraging our knowledge and platform to accelerate your cancer innovations.

  • Use CAR-macrophages to explore targeted phagocytosis in your research.
  • Generate the CAR construct using our existing library.
  • Experiment with activating helper T-cells with CAR-macrophages.
  • Study CAR-macrophages within the tumor microenvironment.

Explore new frontiers in cancer research

Engineering macrophages with CAR allows them to recognize cancer cells more effectively, target specific antigens, trigger phagocytosis, and directly present antigens to helper T-cells. This makes CAR-macrophages an exciting new tool for cancer research, enabling you to develop novel tumor microenvironment research. Our custom development package builds on our extensive knowledge platform and provides you with the resources you need to explore the new frontiers of cancer immunotherapy.

Streamlining Your Preclinical and Clinical Development

By leveraging our extensive CAR construct experience, we were able to develop preclinical and clinical services as part of our CAR-macrophage offering. With our in-house vivarium and 2 GMP manufacturing facilities, we are fully equipped to take care of your CAR-macrophage project needs. 

We offer a range of methods for engaging with our development capabilities, including options for licensing and partnering. Contact us to find out how we can streamline your preclinical and clinical development today.

 

Discovery Services Timelines

Leverage our in vitro and in vivo services to meet all of your discovery needs within one organization, making the process fast and simple for you. Whatever your starting point, you can tailor our discovery services to suit your project and accelerate your research timeline. 

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Develop Antibodies

Create mouse, rabbit, and human monoclonal antibodies using our validated antibody design and development platforms.

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Package Vectors

Innovate your cancer immunotherapies by packaging novel co-expression constructs and any generation of CAR domain into your vectors.

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Scale Production

Expand your research horizons with scalable CAR-macrophage cell production from our GMP manufacturing facilities.

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Ensure Quality

Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with years of CAR immune cell experience.

Service plans and prices

ProMab can help you advance your ideas and technologies with two different plans:

Plan A

Generate the entire construct from a mouse monoclonal antibody or fully human single-chain variable antibody fragment (scFv) from our existing library.

DEVELOPMENT STAGE DESCRIPTION Price
Phase I Immunization of BALB/c mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly presented antigen. $6,995
Phase II Sequencing of the antibody's heavy and light chains. $1,800
Phase III Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Mid-scale generation of high titer (>1x10^8) lentivirus viral particles. $8,500
Phase IV Macrophage-cell isolation, lentiviral transduction, CAR-macrophage culture, and CAR validation by FACS. $7,500
Phase IV-A Phagocytosis Assay by flow cytometry to determine the percentage of CAR-macrophage cells $2,000
Phase IV-B Phagocytosis Assay by phase contrast microscopy to determine the percentage of CAR-macrophage cells $2,000
Phase V Cytokine release assay to measure IL-6, IL-10, and GM-CSF release during target cell engagement. $4,000

Plan B

Construct a CAR based on your antibody sequence.

DEVELOPMENT STAGE DESCRIPTION Price
Phase III

Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Mid-scale generation of high titer (>1x10^8) lentivirus viral particles.

$8,500
Phase IV Macrophage-cell isolation, lentiviral transduction, CAR-macrophage culture, and CAR validation by FACS. $7,500
Phase IV-A Phagocytosis Assay by flow cytometry to determine percentage of CAR-macrophage cells $2,000
Phase IV-B Phagocytosis Assay by phase contrast microscopy to determine percentage of CAR-macrophage cells $2,000
Phase V Cytokine release assay to measure IL-6, IL-10, and GM-CSF release during target cell engagement. $4,000

Explore CAR-macrophages today

We’ll take care of your CAR-macrophage development so that you can focus on insights and innovations. Together, we can change the way the world treats cancer.

5,000+

monoclonal antibodies generated

50+

filed patents

500+

CAR-T project finished

4

Phase 2 clinical trials started

Featured Publications

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells.
Generation of CAR-T Cells for Cancer Immunotherapy.
CAR-T Cells Based on Novel BCMA Monoclonal Antibody Block Multiple Myeloma Cell Growth.

FAQs

What are CAR-macrophages?

Why choose CAR-macrophages over CAR-T cells?

What models do ProMab have to support my CAR-macrophages cell development?

Related Services

Custom Antibody Generation

Advance your antibody R&D with our well-established services designed by specialists with over 2 decades of experience generating highly specific and potent monoclonal antibodies.

Protein Expression

Obtain the protein or peptide of interest for your functional assays, target validation, or antibody development, guided by ProMab’s 22+ years of experience in protein expression and purification services.

Cell Line Engineering

Whether you need ‘ready-made’ or custom cell line development services, our experienced team is here to aid you in CAR-T, CAR-NK, CAR-Macrophage, engineered cell lines, and in vitro validation.