ProMab Biotechnologies offers Dendritic cells (DCs) migration assay service to help our clients understand the pathogenesis of a range of diseases and accelerate their development of gene therapy-based IO products.
ProMab Biotechnologies Custom DC Migration Assays
DCs are central players of the immune system and their migration into secondary lymphoid organs and tissues plays a crucial role in the initiation of innate and adaptive immunity. Immature DCs with strong migration ability are activated by the hapten-protein complex and differentiated from antigen-capture and processing cells into potent immunostimulatory DCs to present antigen effectively to effector T-cells. Most DC driven responses require their migration to a certain target destination to promote immunity.
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Worbs, T.; et al. (2016). Dendritic cell migration in health and disease. Nature Reviews Immunology. 17(1), pp.30-48.