10 Components of the CAR-T/NK Platform
We have plans that include monoclonal antibody development or are based on using your existing antibody sequence to generate the CAR constructs. When client requires antibody developed then Plan A is available starting at $23,750. When client provides antibody sequence Plan B starts at $17,000.
Plan A - Client receives 2 clones of hybridoma cell lines along with 2 x 108 CAR T-cells cryopreserved.
Plan B - Client receives 2 x 108 CAR T-cells cryopreserved.
T-cells come from healthy patient donors.
Service Plans and Prices
PLAN A
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase I (optional) | Immunization of Balb/C mice with recombinant protein or carrier-conjugated peptide.Generation of hybridoma cell lines following antibody validation against the correctly-presented antigen. | $5,150 |
| Phase II (optional) | Sequencing of the antibody's heavy and light chains. | $1,600 |
| Phase III | Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector.Generation of 1x108 lentivirus viral particles. | $6,000 |
| Phase IV | T cell activation, lentiviral transduction, and CAR-T expansion. | $5,000 |
| Phase V | Measurements of CAR expression, INF-γ & IL-2 induction and cytotoxicity. | $6,000 |
PLAN B
| DEVELOPMENT STAGE | DESCRIPTION | PRICE |
|---|---|---|
| Phase III | Synthesis and cloning of an scFv with selected CAR domains into a lentivirus vector. Generation of 1x108 lentivirus viral particles. | $6,000 |
| Phase IV | T cell activation, lentiviral transduction, and CAR-T expansion. | $5,000 |
| Phase V | Measurements of CAR expression, INF-γ & IL-2 induction and cytotoxicity. | $6,000 |
| Phase VI | NSG/NOG xenograft model | starting at $15,000 |
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