CAR-T Cell Design

Accelerate your research by partnering with the field's most experienced CAR-T cell development CRO & CDMO. As the first CRO to offer CAR-T services, we have more years of experience than any other service provider and use our expertise to provide complete solutions for your project.

  • Custom CRO & CDMO services with speedy response times
  • End-to-end solution without the need to manage multiple vendors
  • Experienced scientists maximize your efficiency
  • 10+ years of experience generating CAR-T cells increase your success rates

Choose ProMab For End-to-End Cancer Research & Clinical Development Solutions

We understand that innovative solutions need scientists with the freedom to change the future. To help you harness the power of CAR-Ts in the fight against disease, we offer a complete solution from CAR-T cell design and discovery research to clinical development.

Driving Your Discovery Research Programs

Our CAR-T Platform has 10 core components that are fully customizable and offered in any configuration. A typical service starts with CAR-T cell design, then moves on to selecting the best options for CAR gene delivery, including lentivirus production, mRNA electroporation, and lipid nanoparticle transfection. Finally, through expansion and validation of the finished product, we exercise a full toolbox of functional assays to ensure we meet your performance targets. We continuously iterate at the CAR-T cell engineering stage as needed to achieve your project goals. 

However, if you need CAR-T cell production without custom services, we can manufacture CAR-T cells at scales of 1 x 10^9 cells or more with our large-scale WAVE and G-Rex bioreactors. We follow up T cell expansion with CAR expression validation and functionality testing.

By choosing ProMab for your CAR-T project, you can take advantage of our proprietary and patented innovations—and deep scientific expertise—which include:

⦁    Bispecific scFv engineering
⦁    Novel costimulatory domains
⦁    iCas9 suicide switches
⦁    New detection tags 

Partner with us to benefit from expert advice that will expand the possibilities for your out-of-the-box thinking. 

Advancing Your Preclinical and Clinical Development

Our CAR-T offering also includes the ability to conduct preclinical and clinical development studies supported by our in-house vivarium and 2 GMP manufacturing facilities. With 100+ CAR-T in vivo models built—20+ out-licensed—and 3+ Phase 2 clinical trials initiated, we have the experience to successfully complete your CAR-T discovery and development project needs.

We offer several methods for engaging with our development capabilities, including licensing and partnering—contact us to learn more.

Discovery Services Timelines

Save time with an inclusive in vitro and in vivo service that does everything within a single organization. Whatever your starting point, our end-to-end solution spans discovery and development so that we can tailor our offering around you.

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Monoclonal Antibody Development

Choose from any of our mouse, rabbit, and human antibody development platforms for the validated design and development of your monoclonal antibodies.

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Vector Packaging

Expand the possibilities of your T-cell engineering with the ability to package novel co-expression constructs and any generation of CAR domain into your viral vector.

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Activation and Expansion

Fuel your animal studies with CAR T-cell production up to a large scale and get T-cell activation, lentiviral transduction, and CAR-T expansion that power your validation studies.

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QC measurements

Get reliable CAR expression, cytokine release, and cytotoxicity measurements from our expert team with over 3,000 CAR-T constructs under our belt.

Discovery Services Plans

We offer the following plans for standard projects but can customize a service to meet any project’s needs.

PLAN A

DEVELOPMENT STAGE DESCRIPTION Price
Phase I (optional) Immunization of Balb/C mice with recombinant protein or carrier-conjugated peptide. Generation of hybridoma cell lines following antibody validation against the correctly-presented antigen. $6,995
Phase II (optional) Sequencing of the antibody's heavy and light chains. $1,800
Phase III Synthesis and cloning of a scFv with selected CAR domains into a lentivirus vector. Generation of 1x10^8 lentivirus viral particles. $7,000
Phase IV T cell activation, lentiviral transduction, and CAR-T expansion. Measurement of CAR expression. $6,000
Phase V Cytotoxicity assay, followed by INF-γ & IL-2 measurement by ELISA. $7,000

PLAN B

DEVELOPMENT STAGE DESCRIPTION Price
Phase III Synthesis and cloning of a scFv with selected CAR domains into a lentivirus vector. Generation of 1x10^8 lentivirus viral particles. $7,000
Phase IV T cell activation, lentiviral transduction, and CAR-T expansion. Measurement of CAR Expression. $6,000
Phase V Cytotoxicity assay, followed by INF-γ & IL-2 measurement by ELISA. $7,000
Phase VI NSG/NOG xenograft model Starting at $15,000

Push the Boundaries

We'll take care of your cell line development service project so that you can focus on delivering insights and innovations.

21+

years in antibody engineering

100+

CAR-T cell design projects completed in vivo

500+

in vitro projects in CAR-T cell engineering

3K+

CAR-T and CAR-NK cells generated

Featured Publications

A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells.
Generation of CAR-T Cells for Cancer Immunotherapy.

FAQs

What is CAR-T cell technology?

How are CAR-T cells made?

What is the difference between CAR-T cells and CAR-NK cells?

What models do ProMab have to support my CAR-T cell design and development?

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