Animal Research
ProMab Biotechnologies has the necessary equipment to perform all the work required for doing small animal imaging and much more. We test CAR-T cells in several orthotopic xenograft models, and images metastases using luciferase-positive cell lines. We also provide cancer stem cell models and patient-derived xenograft (PDX) models for testing CAR-T cells.
IMAGING SYSTEM SPECIFICATIONS
The Xenogen IVIS imaging system detects tumor growth using luciferase-positive cancer cells.
ANIMAL STUDIES USE CASE: PM-CD19-CAR-T cells
CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR GROWTH
CD19F-CAR-T IS NOT TOXIC TO MICE (NO LOSS OF MICE BODY WEIGHT)
CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR SIZE
CAR-T CELL MICE HAS INCREASED % HUMAN T CELLS AND % OF HUMAN CD8+ T CELLS
Quickly establish and advance your projects in the following areas with our off-the-shelf solutions:
- CAR-NK cells
- CAR-T cells
- Target cells
- Cancer stem cells
- Cell media
- Expansion/activation platform