Animal Research

ProMab Biotechnologies has the necessary equipment to perform all the work required for doing small animal imaging and much more. We test CAR-T cells in several orthotopic xenograft models, and images metastases using luciferase-positive cell lines. We also provide cancer stem cell models and patient-derived xenograft (PDX) models for testing CAR-T cells.

 

IMAGING SYSTEM SPECIFICATIONS

  The Xenogen IVIS imaging system detects tumor growth using luciferase-positive cancer cells.

ANIMAL STUDIES USE CASE: PM-CD19-CAR-T cells

 
 
  CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR GROWTH

 
CD19F-CAR-T IS NOT TOXIC TO MICE (NO LOSS OF MICE BODY WEIGHT)

  
CD19F-CAR-T SIGNIFICANTLY DECREASES XENOGRAFT TUMOR SIZE

CAR-T CELL MICE HAS INCREASED % HUMAN T CELLS AND % OF HUMAN CD8+ T CELLS

Quickly establish and advance your projects in the following areas with our off-the-shelf solutions:

  • CAR-NK cells
  • CAR-T cells
  • Target cells
  • Cancer stem cells
  • Cell media
  • Expansion/activation platform