Cell Line Engineering > LNP Delivery System for mRNA
LNP Delivery System for mRNA
Efficiently develop the next generation of therapeutics by leaning on ProMab’s expertise in formulation and manufacturing of lipid nanoparticles (LNPs) for gene delivery. Our platform uses a validated mRNA delivery system with proven success in the pharmaceutical industry and is ready to expand the power of your advanced therapeutic.
- Validated & proven workflows
- Designed with field experts
- From discovery to development
- Complete, streamlined service
Choose ProMab for an Elevated R&D Experience
Cellular engineering & gene delivery systems are going to change the world.
Replacing traditional viral vector gene delivery methods with an mRNA delivery system is a smart alternative for generating transient gene expression in immune cells.
As you strive to bring these new treatments to the market, ProMab can streamline your efforts with our mRNA-LNP services. Our validated LNP delivery system enables reliable gene delivery to a range of cell types—including T cells, NK cells, macrophages, dendritic cells, and the other prevalent immune cell subtypes—and can include mRNA design, production, formulation, encapsulation, validation, and scale up.
For researchers taking mRNA-LNP applications to the next level, we offer a critical trio of capabilities that no other vendor can provide, custom antibody generation, CAR-T/NK cell development, and mRNA-LNP services. By combining these three capabilities, you can use mRNA-LNPs to turn tumor cells into cancer vaccines, manufacture antibodies in the body, transform clinical outcomes because you can alter the cell in the body.
The future of medicine is in your hands. We are excited to join you at the cutting edge.
How It Works
Our purpose-built mRNA delivery system can be used alone or with our other services, complete with ready-to-use reagents and custom research advice.
mRNA synthesis by IVT
Hand your mRNA synthesis over to experts with a proven high-throughput in vitro transcription workflow.
mRNA production and validation
We give you confidence in our mRNA delivery system with assurance by electroporation.
Formulation of lipid nanoparticles for mRNA delivery
We streamline the formulation of lipid nanoparticles for mRNA delivery with our built-in validation steps.
Optional LNP delivery services
Enjoy a wide range of other services, including mRNA-LNP scale-up and validation for a range of LNP delivery applications.
See The Quality Of Our LNP Delivery Platform
With our mRNA-LNP delivery platform, we can achieve transient gene expression in multiple cell types. This short-term gene expression delivered to targeted sites has essential advantages for reducing unwanted side effects in the body.
Our proven transfection stability, both with regular stability at 4℃ and through freeze-thaw cycles, enables us to provide resilient cells transfected with ProMab mRNA and delivered via ProMab LNPs.
Use mRNA-LNP Delivery For NK Cell Engineering
CAR-encoding mRNAs are efficiently delivered to and expressed in NK cells using a CAR+ mRNA-LNP construct designed and manufactured by the experienced team at ProMab. Left: Non-transfected NK cell control. Right: NK cell + LNP-CAR formulation.
Use mRNA-LNP Delivery For T Cell Engineering
CAR-encoding mRNAs are efficiently delivered to and expressed in T cells using a CAR+ mRNA-LNP construct designed and manufactured by the experienced team at ProMab. Left: Non-transfected T cell control. Middle: T cell + LNP-CAR formulation detected by mouse Fab-APC. Right: T cell + LNP-CAR formulation detected by mouse Fab-FITC.
Use mRNA-LNPs To Deliver Bispecific Antibodies In Vivo For Anticancer Therapeutic Development
ProMab’s mRNA delivery system transfects cancer cell lines with EpCAM-CD3 hFc mRNA-LNPs enabling them to produce functional antibodies with high antitumor efficacy in vivo. Left: OVCAR-5 cancer cell lines secrete functional EpCAM-CD3-hFc antibody after mRNA-LNP transfection. Middle: EpCAM-CD3 hFc mRNA-LNPs combined with T cells significantly decreased tumor growth. Right: Tumor size and weight significantly decreased with EpCAM-CD3-hFc mRNA-LNP and T cell treatment. See all the data in the paper “mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth.”
Discovery Services Plans
We offer the following plans for standard projects but can customize a service to meet any project’s needs.
| DEVELOPMENT STAGE | DESCRIPTION | Price |
|---|---|---|
| Phase I | mRNA-LNP Design and Synthesis (IVT) | Starting at $2,000 |
| Phase II | mRNA Capping, Purification, and Validation | Starting at $1,500 |
| Phase III | mRNA-LNP Formulation, Encapsulation, and Validation | Starting at $4,000 |
| Phase IV - Optional | mRNA-LNP Scale Up and QC (up to 100mL) | Please Inquire |
| Phase V - Optional | mRNA-LNP Validation In Vivo | Please Inquire |
20+
years delivering outstanding services
100+
projects for mRNA-LNP completed
1K+
mRNA-LNP constructs generated
3+
Out-licensed mRNA-LNP technology
Featured Publications
FAQs
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Related Services
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Advance your antibody R&D with our well-established services designed by specialists with more than 2 decades of experience generating highly specific and potent monoclonal antibodies.
CAR-T/NK Cell Development
Accelerate your CAR-T/NK cell development with ProMab’s complete solution for CAR design, expansion, and validation with a full, customizable toolbox for lentivirus production, mRNA electroporation, and lipid nanoparticle transfection.
Protein Expression
Obtain the protein or peptide of interest for your functional assays, target validation, or antibody development, guided by ProMab’s 22+ years of experience in protein expression and purification services.