PSMA CAR-T cells (PSMA scFv-TM-41BB-CD3z)

PSMA (prostate-specific membrane antigen), encoded by the FOLH1 gene, is a type II membrane protein expressed in the prostate and a number of other organs as well as a number of cancers. Also known as glutamate carboxypeptidase 2 or folate hydrolase 1, PSMA is a peptidase with a preference for tri-alpha-glutamate peptides.

ProMab's PM-CAR1069 primary human CAR-T cells express an anti-PSMA CAR containing a PSMA-specific scFv, hinge and transmembrane domains, the 4-1BB costimulatory domain and the CD3zeta activation domain. The CAR-T cells are generated by transducing activated human T cells with replication-defective lentivirus encoding the CAR. After expansion, the cells are cryopreserved and shipped in vials containing up to 10 million cells. For orders over 10 million cells, please inquire. All ProMab cells are guaranteed to be sterile, pathogen-free and mycoplasma-free.