4-1BBL mRNA-LNP

4-1BB ligand (4-1BBL), also known as tumor necrosis factor ligand superfamily member 9 (TNFSF9) or CD137L, encoded by the TNFSF9 gene, is a type 2 trans Membrane glycoprotein receptor that binds 4-1BB (also known as CD137). This receptor promotes clonal expansion, survival and development of T cells by binding to its receptor 4-1BB. 4-1BBL can also induce peripheral monocyte proliferation, enhance TCR/CD3-triggered activation-induced T cell apoptosis, and modulate CD28 co-stimulation to promote Th1 cell responses. The interaction between 4-1BB and 4-1BBL provides co-stimulatory signals to a variety of T cells and is suggested for the development of cancer immunotherapies. This product is designed as a tool for the delivery and expression of human 4-1BBL mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of 4-1BBL mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The 4-1BBL protein is about 28 kD and consists of 254 amino acids. The GenPept accession number is NP_003802.