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4-1BB ligand (4-1BBL), also known as tumor necrosis factor ligand superfamily member 9 (TNFSF9) or CD137L, encoded by the TNFSF9 gene, is a type 2 trans Membrane glycoprotein receptor that binds 4-1BB (also known as CD137). This receptor promotes clonal expansion, survival and development of T cells by binding to its receptor 4-1BB. 4-1BBL can also induce peripheral monocyte proliferation, enhance TCR/CD3-triggered activation-induced T cell apoptosis, and modulate CD28 co-stimulation to promote Th1 cell responses. The interaction between 4-1BB and 4-1BBL provides co-stimulatory signals to a variety of T cells and is suggested for the development of cancer immunotherapies. This product is designed as a tool for the delivery and expression of human 4-1BBL mRNA for research. The product leverages the lipid nanoparticle (LNP) technology platform for simple and efficient delivery of 4-1BBL mRNA to a variety of mammalian cells in vitro and in vivo. The LNPs used are formulated with SM-102, DSPC, cholesterol and DMG-PEG2000 at an optimal molar concentration for a high rate of encapsulation and efficient mRNA delivery. The 4-1BBL protein is about 28 kD and consists of 254 amino acids. The GenPept accession number is NP_003802.

Product Overview
mRNA-LNPs suspended in PBS (-Ca, -Mg) (pH: 7.0-7.4).
Cell Type Tested
Application & Handing
Upon receiving product, briefly pulse spin before opening to ensure product is at bottom of container. It is important not to spin for too long as this may rupture mRNA-LNPs. Do not vortex. Work with mRNA-LNPs on ice and minimize the time that the product spends at room temperature. After handling the product during experiments, return immediately to ice. mRNA-LNP products should only be handled with certified RNase-free reagents and consumables. Use of filtered pipette tips is highly recommended.
4°C; ice
For Research Use Only. Not for use in diagnostic procedures.