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PCNA Primary Antibody
|Formulation||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.|
|Immunogen||Synthesized peptide derived from internal of human PCNA.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|Species Reactivity||Human, Mouse, Rat|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
Figure 1: Western blot analysis using PCNA Rabbit pAb against HepG2 (1) cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer (left), esophagus cancer tissues (right) using PCNA Rabbit pAb with DAB staining.
|Description||The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome.|
|References (references)||1. Cell. 2010 Jan 8;140(1):123-35.
2. Cancer Invest. 2010 Jul;28(6):635-41.