MSH6 Primary Antibody

Item Information
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Description

This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Product Overview
Entrez GenelD
2956
Aliases
GTBP; HSAP; HNPCC5; MSH6
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from internal of human MSH6.
Formulation
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Am J Surg Pathol. 2009 Dec;33(12):1869-77.
2. Breast Cancer Res Treat. 2010 Sep;123(2):315-20.
Product Image
Western Blot
Figure 1: Western blot analysis using MSH6 Rabbit pAb against HUVE-12 (1), A431 (2), Hela (3) and HCT116 (4) cell lysate.
Figure 1: Western blot analysis using MSH6 Rabbit pAb against HUVE-12 (1), A431 (2), Hela (3) and HCT116 (4) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.