JAK1 Primary Antibody
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
2. Neoplasia. 2010 Jan;12(1):28-38.
![Figure 1: Western blot analysis using JAK1 Rabbit pAb against Hela (1), K562 (2), MCF-7 (3) and A431 (4) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/10029lwb.jpg?v=1666698326)
![Figure 2: Immunohistochemical analysis of paraffin-embedded recta cancer tumor (left), colon cancer tissues (right) using JAK1 Rabbit pAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/10029ihc.jpg?v=1666698326)