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JAK1 Primary Antibody
|Aliases||JTK3; JAK1A; JAK1B; JAK1|
|Formulation||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.|
|Immunogen||Synthesized peptide derived from internal of human JAK1.|
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|Species Reactivity||Human, Mouse, Rat|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
Figure 1: Western blot analysis using JAK1 Rabbit pAb against Hela (1), K562 (2), MCF-7 (3) and A431 (4) cell lysate.
Figure 2: Immunohistochemical analysis of paraffin-embedded recta cancer tumor (left), colon cancer tissues (right) using JAK1 Rabbit pAb with DAB staining.
|Description||Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.|
|References (references)||1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Neoplasia. 2010 Jan;12(1):28-38.