JAK1 Primary Antibody

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Description

Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.

Product Overview
Entrez GenelD
3716
Aliases
JTK3; JAK1A; JAK1B; JAK1
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from internal of human JAK1.
Formulation
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
IHC_P(Immunohistochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Neoplasia. 2010 Jan;12(1):28-38.
Product Image
Western Blot
Figure 1: Western blot analysis using JAK1 Rabbit pAb against Hela (1), K562 (2), MCF-7 (3) and A431 (4) cell lysate.
Figure 1: Western blot analysis using JAK1 Rabbit pAb against Hela (1), K562 (2), MCF-7 (3) and A431 (4) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded recta cancer tumor (left), colon cancer tissues (right) using JAK1 Rabbit pAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded recta cancer tumor (left), colon cancer tissues (right) using JAK1 Rabbit pAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.