JAK1 Primary Antibody

Item Information
Catalog # Size/Concentration Price
10029 100μl $308.00
AliasesJTK3; JAK1A; JAK1B; JAK1
Product OrderJ
Entrez GeneID3716
FormulationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
ImmunogenSynthesized peptide derived from internal of human JAK1.
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C.  Learn More
Species ReactivityHuman, Mouse, Rat
IHC_P (Immunohistochemistry) 1/200 - 1/1000

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Western Blot

Cell Culture Products
Figure 1: Western blot analysis using JAK1 Rabbit pAb against Hela (1), K562 (2), MCF-7 (3) and A431 (4) cell lysate.

Immunohistochemical analysis

Cell Culture Products
Figure 2: Immunohistochemical analysis of paraffin-embedded recta cancer tumor (left), colon cancer tissues (right) using JAK1 Rabbit pAb with DAB staining.
Product Overview
Description Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs.
References (references)
References (references) 1. Am J Hum Genet. 2009 Nov;85(5):628-42.
2. Neoplasia. 2010 Jan;12(1):28-38.

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