Bcr Primary Antibody

Item Information
Catalog #

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.

Product Overview
Entrez GenelD
ALL; CML; PHL; BCR1; D22S11; D22S662; FLJ16453; BCR
Host / Isotype
Rabbit / IgG
Species Reactivity
Human, Mouse, Rat
Synthesized peptide derived from internal of human Bcr.
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Liquid in PBS containing 50% glycerol and 0.03% sodium azide.
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
1. PLoS One. 2009 Oct 30;4(10):e7661.
2. J Biol Chem. 2010 Feb 12;285(7):5085-96.
Product Image
Western Blot
Figure 1: Western blot analysis using Bcr Rabbit pAb against K562 (1) cell lysate.
Figure 1: Western blot analysis using Bcr Rabbit pAb against K562 (1) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.