XPC

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesXP3; RAD4; XPCC; p125
Clone#5F4B11
Entrez GenelD7508
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeMouse IgG1
ImmunogenPurified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.
MW106kDa
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
32-133
Catalog#: 32338
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Images
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using XPC mAb against human XPC (AA: 32-133) recombinant protein. (Expected MW is 41.9 kDa)
Figure 2:Western blot analysis using XPC mAb against human XPC (AA: 32-133) recombinant protein. (Expected MW is 41.9 kDa)
Western Blot
Figure 3:Western blot analysis using XPC mouse mAb against SW480(1) ,A431(2) ,T47D(3) ,HT-29(4) ,A549 (5)and C2C12(6) cell lysate.
Figure 3:Western blot analysis using XPC mouse mAb against SW480(1) ,A431(2) ,T47D(3) ,HT-29(4) ,A549 (5)and C2C12(6) cell lysate.
Immunofluorescence analysis
Figure 4:Flow cytometric analysis of Hela cells using XPC mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of Hela cells using XPC mouse mAb (green) and negative control (red).
Product Overview
Description

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

References (references)
References (references)1,Acta Medica (Hradec Kralove). 2020;63(3):101-112.
2,Nat Commun. 2020 Nov 17;11(1):5834.