The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Purified antibody in PBS with 0.05% sodium azide
4℃; -20℃ for long term storage
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using XPC mAb against human XPC (AA: 32-133) recombinant protein. (Expected MW is 41.9 kDa)
Figure 3:Western blot analysis using XPC mouse mAb against SW480(1) ,A431(2) ,T47D(3) ,HT-29(4) ,A549 (5)and C2C12(6) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using XPC mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.