VAMP2

Item Information
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Description

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.

Product Overview
Entrez GenelD
6844
Aliases
SYB2; VAMP-2; NEDHAHM
Clone#
5A2C7
Host / Isotype
Mouse / Mouse IgG1
Species Reactivity
Human, Mouse, Monkey, Rat
Immunogen
Purified recombinant fragment of human VAMP2 (AA: 2-89aa) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4℃; -20℃ for long term storage
Product Applications
IHC_P(Immunohistochemistry)
1/200 - 1/1000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
Alzheimers Res Ther. 2021 Jun 28;13(1):119.
Cell Mol Immunol. 2018 Apr;15(4):353-366.
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Immunofluorescence analysis
Figure 2:Flow cytometric analysis of Hela cells using VAMP2 mouse mAb (green) and negative control (red).
Figure 2:Flow cytometric analysis of Hela cells using VAMP2 mouse mAb (green) and negative control (red).
Immunofluorescence analysis
Figure 3:Flow cytometric analysis of COS-7 cells using VAMP2 mouse mAb (green) and negative control (red).
Figure 3:Flow cytometric analysis of COS-7 cells using VAMP2 mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 4:Immunohistochemical analysis of paraffin-embedded Medulla oblongata tissues using VAMP2 mouse mAb with DAB staining.
Figure 4:Immunohistochemical analysis of paraffin-embedded Medulla oblongata tissues using VAMP2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded Brain tissues using VAMP2 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded Brain tissues using VAMP2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 6:Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissues using VAMP2 mouse mAb with DAB staining.
Figure 6:Immunohistochemical analysis of paraffin-embedded Mouse cerebellum tissues using VAMP2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 7:Immunohistochemical analysis of paraffin-embedded Rat brain tissues using VAMP2 mouse mAb with DAB staining.
Figure 7:Immunohistochemical analysis of paraffin-embedded Rat brain tissues using VAMP2 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 8:Immunohistochemical analysis of paraffin-embedded Rabbit brain tissues using VAMP2 mouse mAb with DAB staining.
Figure 8:Immunohistochemical analysis of paraffin-embedded Rabbit brain tissues using VAMP2 mouse mAb with DAB staining.
For Research Use Only. Not for use in diagnostic procedures.