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ULBP2 Primary Antibody
|Aliases||N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human ULBP2 (AA: 26-216) expressed in E. Coli.|
|ICC (Immunocytochemistry)||1/500 - 1/2000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using ULBP2 mAb against human ULBP2 (AA: 26-216) recombinant protein. (Expected MW is 47.6 kDa)
Figure 3:Western blot analysis using ULBP2 mAb against HEK293 (1) and ULBP2 (AA: 26-216)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using ULBP2 mouse mAb (green) and negative control (red).
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
|References (references)||1.Yonago Acta Med. 2015 Mar;58(1):31-8. 2.PLoS One. 2014 Mar 10;9(3):e91133.|