TNNT2

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6
Clone#4B1D5
Entrez GenelD7139
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeMouse IgG1
ImmunogenPurified recombinant fragment of human TNNT2 (AA: 1-295) expressed in E. Coli.
MW35.9kDa
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
FULL(1-295)
Catalog#: 32270
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Images
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using TNNT2 mAb against human TNNT2 (AA: 1-295) recombinant protein. (Expected MW is 61.5 kDa)
Figure 2:Western blot analysis using TNNT2 mAb against human TNNT2 (AA: 1-295) recombinant protein. (Expected MW is 61.5 kDa)
Western Blot
Figure 3:Western blot analysis using TNNT2 mAb against HEK293-6e (1) and TNNT2 (AA: 1-295)-hIgGFc transfected HEK293-6e (2) cell lysate.
Figure 3:Western blot analysis using TNNT2 mAb against HEK293-6e (1) and TNNT2 (AA: 1-295)-hIgGFc transfected HEK293-6e (2) cell lysate.
Immunofluorescence analysis
Figure 4:Flow cytometric analysis of LNcap cells using TNNT2 mouse mAb (green) and negative control (red).
Figure 4:Flow cytometric analysis of LNcap cells using TNNT2 mouse mAb (green) and negative control (red).
Immunohistochemical analysis
Figure 5:Immunohistochemical analysis of paraffin-embedded cardiac muscle tissues using TNNT2 mouse mAb with DAB staining.
Figure 5:Immunohistochemical analysis of paraffin-embedded cardiac muscle tissues using TNNT2 mouse mAb with DAB staining.
Product Overview
Description

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined.

References (references)
References (references)1.Biomarkers. 2020 Dec;25(8):626-633.
2.Biomarkers. 2020 Dec;25(8):613-615.