TNFRSF11B Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesOPG; TR1; OCIF; MGC29565; TNFRSF11B
ProductOrderT
Clone#5A11
Entrez GenelD4982
FormulationAscitic fluid containing 0.03% sodium azide.

HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human TNFRSF11B expressed in E. Coli.
MW60kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
22-401
Catalog#: 30136
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Images
Western Blot
Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and lung cancer tissues (right) using TNFRSF11B mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and lung cancer tissues (right) using TNFRSF11B mouse mAb with DAB staining.
Product Overview
Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

References (references)
References (references)1. Am J Hypertens. 2009 Nov;22(11):1167-70.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.