TNFRSF11B Primary Antibody

Item Information

Catalog #

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Price

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Product Overview

Entrez GenelD

4982

Aliases

OPG; TR1; OCIF; MGC29565; TNFRSF11B

Clone#

5A11

Host / Isotype

Mouse / IgG1

Species Reactivity

Human

Immunogen

Purified recombinant fragment of human TNFRSF11B expressed in E. Coli.

Formulation

Ascitic fluid containing 0.03% sodium azide.

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Product Applications

WB (Western Blot)

1/500 - 1/2000

IHC_P(Immunohistochemistry)

1/200 - 1/1000

ELISA

1/10000

References

1. Am J Hypertens. 2009 Nov;22(11):1167-70.
2. Am J Hum Genet. 2009 Nov;85(5):628-42.

Product Image

Western Blot

Figure 1: Western blot analysis using TNFRSF11B mAb against HEK293 (1) and TNFRSF11B(AA: 22-401)-hIgGFc transfected HEK293 (2) cell lysate.

Immunohistochemical analysis

Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and lung cancer tissues (right) using TNFRSF11B mouse mAb with DAB staining.

For Research Use Only. Not for use in diagnostic procedures.