TIE1 Primary Antibody
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purified antibody from tissue culture in PBS with 0.05% sodium azide
4°C; -20°C for long term storage
Figure 1: Western blot analysis using TIE1 mAb against human TIE1 (AA: 385-607) recombinant protein. (Expected MW is 50.6 kDa)
Figure 2: Western blot analysis using TIE1 mAb against HEK293 (1) and TIE1 (AA: 385-607)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 3: Western blot analysis using TIE1 mouse mAb against HepG2 cell lysate.
Figure 4: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using TIE1 mouse mAb with DAB staining.
Figure 5: Immunohistochemical analysis of paraffin-embedded kidney tissues using TIE1 mouse mAb with DAB staining.
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.