TFRC Primary Antibody

Item Information

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Price

Description

Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses.

Product Overview

Entrez GenelD

7037

Aliases

T9; TR; TFR; p90; CD71; TFR1; TRFR

Clone#

1A1B2

Host / Isotype

Mouse / IgG1

Species Reactivity

Human, Mouse, Monkey, Rat

Immunogen

Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.

Formulation

Purified antibody in PBS with 0.05% sodium azide

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Product Applications

WB (Western Blot)

1/500 - 1/2000

ELISA

1/10000

References

1. Folia Histochem Cytobiol. 2012 Jul 5;50(2):304-11.
2. J Biol Chem. 2011 Oct 14;286(41):35708-15.

Product Image

Western Blot

Figure 1: Western blot analysis using TFRC mAb against human TFRC recombinant protein. (Expected MW is 39.7 kDa)

Western Blot

Figure 2: Western blot analysis using TFRC mAb against HEK293 (1) and TFRC (AA: 608-727)-hIgGFc transfected HEK293 (2) cell lysate.

Western Blot

Figure 3: Western blot analysis using TFRC mouse mAb against Jurkat (1), Hela (2), K562 (3), Cos7 (4), MCF-7 (5), PC-12 (6), NIH/3T3 (7), HEK293 (8), RAJI (9) cell lysate.

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