TERT Primary Antibody

Item Information
Catalog # Size/Concentration Price
30809 100μl $341.00
Product OrderT
Entrez GeneID7015
FormulationPurified antibody in PBS with 0.05% sodium azide
ImmunogenPurified recombinant fragment of human TERT (AA: 1029-1132) expressed in E. Coli.
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C.  Learn More
Species ReactivityHuman
IHC_P (Immunohistochemistry) 1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000

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Cell Culture Products
Figure 1: Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);

Western Blot

Cell Culture Products
Figure 2:Western blot analysis using TERT mAb against human TERT (AA: 1029-1132) recombinant protein. (Expected MW is 37.1 kDa)

Western Blot

Cell Culture Products
Figure 3:Western blot analysis using TERT mAb against HEK293 (1) and TERT (AA: 1029-1132)-hIgGFc transfected HEK293 (2) cell lysate.

Flow cytometric

Cell Culture Products
Figure 4:Flow cytometric analysis of Hela cells using TERT mouse mAb (green) and negative control (red).

Immunohistochemical analysis

Cell Culture Products
Figure 5:Immunohistochemical analysis of paraffin-embedded colon cancer tissues using TERT mouse mAb with DAB staining.

Immunohistochemical analysis

Cell Culture Products
Figure 6:Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using TERT mouse mAb with DAB staining.
Tissue Array Results
Position Tissues Name Result Localization
Nucleus Cytoplasm Membrane
A1/2 Esophageal Cancer +
B1/2 Esophageal Cancer +
C1/2 Esophagus +
D1/2 Esophagus +
E1/2 Stomach Cancer +
F1/2 Stomach Cancer +
G1/2 Stomach -
H1/2 Stomach +
A3/4 Colon Cancer +
B3/4 Colon Cancer +
C3/4 Colon +
D3/4 Duodenum +
E3/4 Rectal Cancer +
F3/4 Rectal Cancer +
G3/4 Rectum +
H3/4 Testis +
A5/6 Hepatic Carcinoma +
B5/6 Hepatic Carcinoma +
C5/6 Liver +
D5/6 Renal cell Carcinoma +
E5/6 Kidney +
F5/6 Pancreas +
G5/6 Prostate Cancer +
H5/6 Lymphoid tissue -
A7/8 Lung Cancer +
C7/8 Lung +
D7/8 Brain +
E7/8 Brain +
F7/8 Medulla oblongata +
G7/8 Cerebellar +
H7/8 Skeletal muscle -
A9/10 Breast Cancer +
B9/10 Breast Cancer +
C9/10 Ovarian Cancer +
D9/10 Ovarian Cancer +
E9/10 Endometrial Cancer +
F9/10 Cervical Cancer +
G9/10 Bladder Cancer +
H9/10 Myocardial -
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Product Overview
Description Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
References (references)
References (references) 1.Cancer Res. 2013 Dec 15;73(24):7162-7.
2.PLoS One. 2013 Sep 25;8(9):e75253.

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