TCL1A Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesTCL1
ProductOrderT
Clone#2E3A5
Entrez GenelD8115
FormulationPurified antibody in PBS with 0.05% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human TCL1A (AA: 10-104) expressed in E. Coli.
MW13.5kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
10-104
Catalog#: 30715
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Images
Western Blot
Figure 1: Western blot analysis using TCL1A mAb against human TCL1A (AA: 10-104) recombinant protein. (Expected MW is 37.3 kDa)
Figure 1: Western blot analysis using TCL1A mAb against human TCL1A (AA: 10-104) recombinant protein. (Expected MW is 37.3 kDa)
Western Blot
Figure 2: Western blot analysis using TCL1A mAb against HEK293 (1) and TCL1A (AA: 10-104)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using TCL1A mAb against HEK293 (1) and TCL1A (AA: 10-104)-hIgGFc transfected HEK293 (2) cell lysate.
Flow cytometric
Figure 3: Flow cytometric analysis of Hela cells using TCL1A mouse mAb (green) and negative control (red).
Figure 3: Flow cytometric analysis of Hela cells using TCL1A mouse mAb (green) and negative control (red).
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
Description

Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).

References (references)
References (references)1. Blood. 2012 Aug 23;120(8):1613-23.
2. Histopathology. 2010 Jul;57(1):152-7.