STK11 Primary Antibody
Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
2. Sci Signal. 2009 Sep 1;2(86):pe55.
![Figure 1: Western blot analysis using STK11 mouse mAb against NIH/3T3 (1),Raw246.7 (2), COS7 (3), Jurkat (4), HEK293 (5) and A431 (6) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30139lwb.jpg?v=1666699171)
![Figure 2: Flow cytometric analysis of K562 cells using STK11 mouse mAb (green) and negative control (purple).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30139fcm.jpg?v=1666699171)