STK11 Primary Antibody
Item Information
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Size
Price
Description
Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.
Product Overview
Entrez GenelD
6794
Aliases
PJS; LKB1; STK11
Clone#
4H12
Host / Isotype
Mouse / IgG1
Species Reactivity
Human, Mouse, Monkey
Immunogen
Purified recombinant fragment of human STK11 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
FCM (Flow Cytometry)
1/200 - 1/400
ELISA
1/10000
References
1. Sci Signal. 2009 Jul 21;2(80):ra35.
2. Sci Signal. 2009 Sep 1;2(86):pe55.
2. Sci Signal. 2009 Sep 1;2(86):pe55.
Product Image
Western Blot
Figure 1: Western blot analysis using STK11 mouse mAb against NIH/3T3 (1),Raw246.7 (2), COS7 (3), Jurkat (4), HEK293 (5) and A431 (6) cell lysate.
Flow cytometric
Figure 2: Flow cytometric analysis of K562 cells using STK11 mouse mAb (green) and negative control (purple).
For Research Use Only. Not for use in diagnostic procedures.