STAT5B Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesSTAT5; STAT5B
ProductOrderS
Clone#5B3
Entrez GenelD6777
FormulationAscitic fluid containing 0.03% sodium azide.

HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human STAT5B expressed in E. Coli.
MW90kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
661-787
Catalog#: 30074
Inquire
Contact us to order
Images
Western Blot
Figure 1: Western blot analysis using STAT5B mouse mAb against Hela (1), K562 (2), NIH/3T3 (3), C6 (4), HEK293 (5), Jurkat (6) and HL-60 (7) cell lysate.
Figure 1: Western blot analysis using STAT5B mouse mAb against Hela (1), K562 (2), NIH/3T3 (3), C6 (4), HEK293 (5), Jurkat (6) and HL-60 (7) cell lysate.
Product Overview
Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

References (references)
References (references)1. Mol Cancer. 2009 Aug 26;8:67.
2. Bone. 2010 Feb;46(2):524-33.