SOX2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesANOP3; MCOPS3
ProductOrderS
Clone#10F10
Entrez GenelD6657
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human SOX2 expressed in E. Coli.
MW34kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
1-170
Catalog#: 30144
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Images
Western Blot
Figure 1: Western blot analysis using SOX2 mAb against HEK293 (1) and SOX2(AA: 2-317)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using SOX2 mAb against HEK293 (1) and SOX2(AA: 2-317)-hIgGFc transfected HEK293 (2) cell lysate.
Immunofluorescence analysis
Figure 2: Immunofluorescence analysis of NTERA-2 cells using SOX2 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Figure 2: Immunofluorescence analysis of NTERA-2 cells using SOX2 mouse mAb (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and esophageal cancer tissues (right) using SOX2 mouse mAb with DAB staining.
Figure 3: Immunohistochemical analysis of paraffin-embedded lung cancer tissues (left) and esophageal cancer tissues (right) using SOX2 mouse mAb with DAB staining.
Product Overview
Description

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

References (references)
References (references)1. Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18396-401.
2. J Biol Chem. 2008 Nov 28;283(48):33730-5.
3. Nature. 2008 Oct 23;455(7216):1124-8.
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