SNAI2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesSLUG; WS2D; SLUGH1; MGC10182; SNAI2
ProductOrderS
Clone#2H5
Entrez GenelD6591
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human SNAI2 expressed in E. Coli.
MW30kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
1-128
Catalog#: 30037
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Images
Western Blot
Figure 1: Western blot analysis using SNAI2 mouse mAb against SNAI2(AA: 1-128)-hIgGFc transfected HEK293 cell lysate.
Figure 1: Western blot analysis using SNAI2 mouse mAb against SNAI2(AA: 1-128)-hIgGFc transfected HEK293 cell lysate.
Product Overview
Description

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ?-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

References (references)
References (references)1. Biochem J. 2008 Dec 1;416(2):179-87.
2. Mol Biol Cell. 2008 Nov;19(11):4875-87.
3. Am J Pathol. 2009 Jun;174(6):2107-15.