SNAI2 Primary Antibody
Item Information
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Size
Price
Description
This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in ?-irradiated cells; Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.
Product Overview
Entrez GenelD
6591
Aliases
SLUG; WS2D; SLUGH1; MGC10182; SNAI2
Clone#
2H5
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human SNAI2 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Biochem J. 2008 Dec 1;416(2):179-87.
2. Mol Biol Cell. 2008 Nov;19(11):4875-87.
3. Am J Pathol. 2009 Jun;174(6):2107-15.
2. Mol Biol Cell. 2008 Nov;19(11):4875-87.
3. Am J Pathol. 2009 Jun;174(6):2107-15.
Product Image
Western Blot
Figure 1: Western blot analysis using SNAI2 mouse mAb against SNAI2(AA: 1-128)-hIgGFc transfected HEK293 cell lysate.
For Research Use Only. Not for use in diagnostic procedures.