SNAI1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesSNA; SNAH; SLUGH2; dJ710H13.1; SNAI1
ProductOrderS
Clone#6D2
Entrez GenelD6615
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human SNAI1 expressed in E. Coli.
MW29kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
full(2-264), must use Pet21 or PQE30
Catalog#: 30145
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Images
Western Blot
Figure 1: Western blot analysis using SNAI1 mAb against human SNAI1 (AA: 2-264) recombinant protein. (Expected MW is 31.3 kDa)
Figure 1: Western blot analysis using SNAI1 mAb against human SNAI1 (AA: 2-264) recombinant protein. (Expected MW is 31.3 kDa)
Western Blot
Figure 2: Western blot analysis using SNAI1 mouse mAb against NTERA-2 cell lysate.
Figure 2: Western blot analysis using SNAI1 mouse mAb against NTERA-2 cell lysate.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

References (references)
References (references)1. Exp Cell Res. 2008 Aug 1;314(13):2448-53.
2. Mol Cell Biol. 2008 Aug;28(15):4772-81.