SNAI1 Primary Antibody
Item Information
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Size
Price
Description
Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.
Product Overview
Entrez GenelD
6615
Aliases
SNA; SNAH; SLUGH2; dJ710H13.1; SNAI1
Clone#
6D2
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human SNAI1 expressed in E. Coli.
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Exp Cell Res. 2008 Aug 1;314(13):2448-53.
2. Mol Cell Biol. 2008 Aug;28(15):4772-81.
2. Mol Cell Biol. 2008 Aug;28(15):4772-81.
Product Image
Western Blot
Figure 1: Western blot analysis using SNAI1 mAb against human SNAI1 (AA: 2-264) recombinant protein. (Expected MW is 31.3 kDa)
Western Blot
Figure 2: Western blot analysis using SNAI1 mouse mAb against NTERA-2 cell lysate.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
For Research Use Only. Not for use in diagnostic procedures.