SKP1 Primary Antibody
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
2.Cell. 2009 Jul 23;138(2):389-403.
![Figure 1: Western blot analysis using SKP1 mAb against human SKP1 (AA: 1-160) recombinant protein. (Expected MW is 50 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316rwb.jpg?v=1666699672)
![Figure 2: Western blot analysis using SKP1 mouse mAb against Hela (1), RAJI (2), Jurkat (3), MCF-7 (4), HepG2 (5), PC-12 (6) and Cos7 (7) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316lwb.jpg?v=1666699672)
![Figure 3: Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using SKP1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316ihc-1.jpg?v=1666699672)
![Figure 4: Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using SKP1 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316ihc-2.jpg?v=1666699672)
![Figure 5: Flow cytometric analysis of Hela cells using SKP1 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316fcm.jpg?v=1666699672)
![Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30316ea.jpg?v=1666699672)