SETD7 Primary Antibody
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3. H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates Lys-189 of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
2.Sci Rep. 2015 Oct 5;5:14368.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31680ea.jpg?v=1666704290)
![Figure 2:Western blot analysis using SETD7 mAb against human SETD7 (AA: 107-366) recombinant protein. (Expected MW is 55 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31680rwb.jpg?v=1666704290)
![Figure 3:Western blot analysis using SETD7 mAb against HEK293 (1) and SETD7 (AA: 107-366)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31680twb.jpg?v=1666704290)
![Figure 4:Western blot analysis using SETD7 mouse mAb against MCF-7 (1), Hela (2), A549 (3), COS7 (4), Jurkat (5), and PC-12 (6) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31680lwb.jpg?v=1666704290)
![Figure 5:Immunohistochemical analysis of paraffin-embedded Hela tissues using SETD7 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31680ihc.jpg?v=1666704290)