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SDHB Primary Antibody
|Aliases||IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Immunogen||Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.|
|IHC_P (Immunohistochemistry)||1/200 - 1/1000|
|FCM (Flow Cytometry)||1/200 - 1/400|
|WB (Western Blot)||1/500 - 1/2000|
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 2:Western blot analysis using SDHB mAb against human SDHB (AA: 29-280) recombinant protein. (Expected MW is 31.7 kDa)
Figure 3:Western blot analysis using SDHB mAb against HEK293 (1) and SDHB (AA: 29-280)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 4:Flow cytometric analysis of Hela cells using SDHB mouse mAb (green) and negative control (red).
Figure 5:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using SDHB mouse mAb with DAB staining.
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
|References (references)||1.Endocrine. 2017 Sep;57(3):512-517. 2.J Natl Cancer Inst. 2016 Jan;108(1).|