SDHB Primary Antibody

Item Information
Catalog # Size/Concentration Price
31841 100ug $341.00
Specification
AliasesIP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Clone#2B2B1
Entrez GeneID6390
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeMouse IgG1
ImmunogenPurified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.
MW31.6kDa
Application
ELISA1/10000
IHC_P (Immunohistochemistry) 1/200 - 1/1000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Catalog
31841
$341.00
-
+

Contact us to order

Images

Elisa

Cell Culture Products

Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

Western Blot

Cell Culture Products

Figure 2:Western blot analysis using SDHB mAb against human SDHB (AA: 29-280) recombinant protein. (Expected MW is 31.7 kDa)

Western Blot

Cell Culture Products

Figure 3:Western blot analysis using SDHB mAb against HEK293 (1) and SDHB (AA: 29-280)-hIgGFc transfected HEK293 (2) cell lysate.

Flow cytometric

Cell Culture Products

Figure 4:Flow cytometric analysis of Hela cells using SDHB mouse mAb (green) and negative control (red).

Immunohistochemical analysis

Cell Culture Products

Figure 5:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using SDHB mouse mAb with DAB staining.

Product Overview
Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

References (references)
References (references) 1.Endocrine. 2017 Sep;57(3):512-517. 2.J Natl Cancer Inst. 2016 Jan;108(1).

Please view FAQs here