SDC1 Primary Antibody
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
2. PLoS One. 2011;6(9):e25252.
![Figure 1: Western blot analysis using SDC1 mAb against human SDC1 (AA: 28-171) recombinant protein. (Expected MW is 44.4 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658rwb.jpg?v=1666700611)
![Figure 2: Western blot analysis using SDC1 mAb against HEK293 (1) and SDC1 (AA: 28-171)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658twb.jpg?v=1666700611)
![Figure 3: Western blot analysis using SDC1 mouse mAb against Hela (1), MCF-7 (2), HepG2 (3), T47D (4), Jurkat (5), NIH/3T3 (6) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658lwb.jpg?v=1666700611)
![Figure 4: Immunofluorescence analysis of HepG2 cells using SDC1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Secondary antibody from Fisher (Cat#: 35503)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658icc.jpg?v=1666700611)
![Figure 5: Flow cytometric analysis of A431 cells using SDC1 mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658fcm.jpg?v=1666700611)
![Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/30658ea.jpg?v=1666700611)