ROR1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesROR1
ProductOrderR
Clone#2H6
Entrez GenelD4919
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenRecombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
MW101kDa
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Species ReactivityHuman
Application
ELISA1/10000
ICC (Immunocytochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
Extra(30-406)71.7
Catalog#: 20372
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Images
Immunofluorescence analysis
Figure 1: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 1: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Western Blot
Figure 2: Western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).
Figure 2: Western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).
Product Overview
Description

ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

References (references)
References (references)1. J Cell Sci. 2005 Jan 15;118(Pt 2):433-46.
2. Oncogene. 1996 Oct 3;13(7):1555-9.