ROR1 Primary Antibody

Item Information
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Description

ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

Product Overview
Entrez GenelD
4919
Aliases
ROR1
Clone#
2H6
Host / Isotype
Mouse / IgG1
Species Reactivity
Human
Immunogen
Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ICC (Immunocytochemistry)
1/200 - 1/1000
ELISA
1/10000
References
1. J Cell Sci. 2005 Jan 15;118(Pt 2):433-46.
2. Oncogene. 1996 Oct 3;13(7):1555-9.
Product Image
Immunofluorescence analysis
Figure 1: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Figure 1: Confocal Immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.
Western Blot
Figure 2: Western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).
Figure 2: Western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).
For Research Use Only. Not for use in diagnostic procedures.