PTPRF Primary Antibody
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
2.Hepatology. 2014 Jun;59(6):2238-50.
![Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31557ea.jpg?v=1666703938)
![Figure 2:Western blot analysis using PTPRF mAb against human PTPRF (AA: extra 1104-1163) recombinant protein. (Expected MW is 44.5 kDa)](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31557rwb.jpg?v=1666703938)
![Figure 3:Western blot analysis using PTPRF mAb against HEK293 (1) and PTPRF (AA: extra 1104-1163)-hIgGFc transfected HEK293 (2) cell lysate.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31557twb.jpg?v=1666703938)
![Figure 4:Flow cytometric analysis of HL-60 cells using PTPRF mouse mAb (green) and negative control (red).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/31557fcm.jpg?v=1666703938)