PTPRC Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesLCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180
ProductOrderP
Clone#2C10C11
Entrez GenelD5788
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PTPRC (AA: 928-989) expressed in E. Coli.
MW147.3kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
928-989
Catalog#: 30586
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Images
Western Blot
Figure 1: Western blot analysis using PTPRC mAb against human PTPRC (AA: 928-989) recombinant protein. (Expected MW is 33 kDa)
Figure 1: Western blot analysis using PTPRC mAb against human PTPRC (AA: 928-989) recombinant protein. (Expected MW is 33 kDa)
Western Blot
Figure 2: Western blot analysis using PTPRC mAb against HEK293 (1) and PTPRC (AA: 928-989)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using PTPRC mAb against HEK293 (1) and PTPRC (AA: 928-989)-hIgGFc transfected HEK293 (2) cell lysate.
Western Blot
Figure 3: Western blot analysis using PTPRC mouse mAb against Hela (1) and A431 (2) cell lysate.
Figure 3: Western blot analysis using PTPRC mouse mAb against Hela (1) and A431 (2) cell lysate.
Immunohistochemical analysis
Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using PTPRC mouse mAb with DAB staining.
Figure 4: Immunohistochemical analysis of paraffin-embedded colon cancer tissues using PTPRC mouse mAb with DAB staining.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
DescriptionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

References (references)
References (references)1. Biochem Biophys Res Commun. 2012 Mar 23;419(4):708-14.
2. Blood. 2009 Jun 4;113(23):5905-10.