PTP4A2 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesHH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
ProductOrderP
Clone#5B6F4
Entrez GenelD8073
FormulationPurified antibody in PBS with 0.05% sodium azide
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human PTP4A2 (AA: 58-162) expressed in E. Coli.
MW19.1kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
58-162
Catalog#: 30563
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Images
Western Blot
Figure 1: Western blot analysis using PTP4A2 mAb against human PTP4A2 recombinant protein. (Expected MW is 37.5 kDa)
Figure 1: Western blot analysis using PTP4A2 mAb against human PTP4A2 recombinant protein. (Expected MW is 37.5 kDa)
Western Blot
Figure 2: Western blot analysis using PTP4A2 mAb against HEK293 (1) and PTP4A2 (AA: 58-162)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using PTP4A2 mAb against HEK293 (1) and PTP4A2 (AA: 58-162)-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
Product Overview
DescriptionThe protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
References (references)
References (references)1. Cancer Res. 2010 Nov 1;70(21):8959-67.
2. Blood Cells Mol Dis. 2010 Apr 15;44(4):209-14.