PTP4A2 Primary Antibody
Item Information
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Price
Description
The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17.
Product Overview
Entrez GenelD
8073
Aliases
HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b
Clone#
5B6F4
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human PTP4A2 (AA: 58-162) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Cancer Res. 2010 Nov 1;70(21):8959-67.
2. Blood Cells Mol Dis. 2010 Apr 15;44(4):209-14.
2. Blood Cells Mol Dis. 2010 Apr 15;44(4):209-14.
Product Image
Western Blot
Figure 1: Western blot analysis using PTP4A2 mAb against human PTP4A2 recombinant protein. (Expected MW is 37.5 kDa)
Western Blot
Figure 2: Western blot analysis using PTP4A2 mAb against HEK293 (1) and PTP4A2 (AA: 58-162)-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);
For Research Use Only. Not for use in diagnostic procedures.