PTK7 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCCK4; PTK7
ProductOrderP
Clone#4F9
Entrez GenelD5754
FormulationAscitic fluid containing 0.03% sodium azide.

HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PTK7 expressed in E. Coli.
MW118kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
31-199
Catalog#: 30078
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Images
Western Blot
Figure 1: Western blot analysis using PTK7 mouse mAb against Hela (1), A431 (2), HCT116 (3), Caco2 (4), HepG2 (5) and MCF-7 (6) cell lysate.
Figure 1: Western blot analysis using PTK7 mouse mAb against Hela (1), A431 (2), HCT116 (3), Caco2 (4), HepG2 (5) and MCF-7 (6) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PTK7 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PTK7 mouse mAb with DAB staining.
Product Overview
Description

Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene.Tissue specificity: Highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes. Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle. Also expressed in erythroleukemia cells. But not expressed in colon.

References (references)
References (references)1. Oncogene. 1995 Nov 16;11(10):2179-84.
2. Cytogenet Cell Genet. 1997;76(1-2):43-4.
3. Biochem Biophys Res Commun. 2008 Jul 11;371(4):793-8.