PTK6 Primary Antibody

Item Information
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Description

PTK6 (protein tyrosine kinase 6, BRK or FLJ42088), with 451-amino acid protein (about 52kDa), encods a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Its presence in the nucleus appears to be linked to suppression of tumor progression. The encoded protein has been shown to undergo autophosphory-lation. Very high level in colon and high levels in small intestine and prostate, and low levels in some fetal tissues. And Expressed at low level in some breast tumors, but not in normal breast. Also found in melanocytes, but not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype.

Product Overview
Entrez GenelD
5753
Aliases
BRK; FLJ42088
Clone#
2H12B8
Host / Isotype
Mouse / IgG2b
Species Reactivity
Human
Immunogen
Purified recombinant fragment of human PTK6 expressed in E. Coli.

Formulation
Ascitic fluid containing 0.03% sodium azide.
Storage
4°C; -20°C for long term storage
Product Applications
WB (Western Blot)
1/500 - 1/2000
ELISA
1/10000
References
1. Wilks, A.F. Proc. Natl. Acad. Sci. USA 86: 1603-1607.
2. Ottilie, S., et al. Oncogene 7: 1625-1630.
3. Lee, S.T., et al. Oncogene 8: 3403-3410.
Product Image
Western Blot
Figure 1: Western blot analysis using PTK6 mouse mAb against Hela (1), A549 (2) and MCF-7 (3) cell lysate.
Figure 1: Western blot analysis using PTK6 mouse mAb against Hela (1), A549 (2) and MCF-7 (3) cell lysate.
For Research Use Only. Not for use in diagnostic procedures.