PROZ Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Aliasesprotein Z; PZ
Entrez GenelD8858
FormulationAscitic fluid containing 0.03% sodium azide.
ImmunogenPurified recombinant fragment of PROZ expressed in E. Coli.
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
WB (Western Blot)1/500 - 1/2000
Catalog#: 20362
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Western Blot
Figure 1: Western blot analysis using PROZ mouse mAb against human plasma (1).
Figure 1: Western blot analysis using PROZ mouse mAb against human plasma (1).
Product Overview

PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

References (references)
References (references)1. J Thromb Haemost. 2005 Mar;3(3):497-501.
2. Blood Coagul Fibrinolysis. 2008 Jan;19(1):23-5.