PLAU

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Description

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

Product Overview
Formulation
Purified antibody in PBS with 0.05% sodium azide
Storage
4℃; -20℃ for long term storage
Product Image
Elisa
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
Western Blot
Figure 2:Western blot analysis using PLAU mAb against human PLAU (AA: 107-379) recombinant protein. (Expected MW is 34 kDa)
Figure 2:Western blot analysis using PLAU mAb against human PLAU (AA: 107-379) recombinant protein. (Expected MW is 34 kDa)
Western Blot
Figure 4:Western blot analysis using PLAU mouse mAb against PC-3 (1),MCF-7 (2), LNCap (3),DU145 (4),HCT116 (5),A549 (6),SK-OV-3 (7) and HEK293 (8) cell lysate.
Figure 4:Western blot analysis using PLAU mouse mAb against PC-3 (1),MCF-7 (2), LNCap (3),DU145 (4),HCT116 (5),A549 (6),SK-OV-3 (7) and HEK293 (8) cell lysate.
Immunohistochemical analysis
Figure 5:Immunofluorescence analysis of Hela cells using PLAU mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Figure 5:Immunofluorescence analysis of Hela cells using PLAU mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
Immunofluorescence analysis
Figure 6:Flow cytometric analysis of Hela cells using PLAU mouse mAb (green) and negative control (red).
Figure 6:Flow cytometric analysis of Hela cells using PLAU mouse mAb (green) and negative control (red).
Immunofluorescence analysis
Figure 7:Flow cytometric analysis of HepG2 cells using PLAU mouse mAb (green) and negative control (red).
Figure 7:Flow cytometric analysis of HepG2 cells using PLAU mouse mAb (green) and negative control (red).
For Research Use Only. Not for use in diagnostic procedures.