PGC-1alpha Primary Antibody
|Aliases||PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Immunogen||Purified recombinant fragment of human PGC-1alpha expressed in E. Coli. |
|Shipping Information||This product will ship in a box containing blue ice at a temperature of 4°C. Learn More|
|WB (Western Blot)||1/500 - 1/2000|
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Figure 1: Western blot analysis using PGC-1alpha mAb against human PGC-1alpha (AA: 570-798) recombinant protein. (Expected MW is 70 kDa)
Figure 2: Western blot analysis using PGC-1alpha mAb against HEK293 (1) and PGC-1alpha-hIgGFc transfected HEK293 (2) cell lysate.
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
|References (references)||1. Diabetes Res Clin Pract. 2009 Dec;86(3):168-72. |
2.Cell Metab. 2009 Sep;10(3):189-98.