PGC-1alpha Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesPPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)
ProductOrderP
Clone#1G8
Entrez GenelD10891
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG2b
ImmunogenPurified recombinant fragment of human PGC-1alpha expressed in E. Coli.
MW91kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
570-798
Catalog#: 30265
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Images
Western Blot
Figure 1: Western blot analysis using PGC-1alpha mAb against human PGC-1alpha (AA: 570-798) recombinant protein. (Expected MW is 70 kDa)
Figure 1: Western blot analysis using PGC-1alpha mAb against human PGC-1alpha (AA: 570-798) recombinant protein. (Expected MW is 70 kDa)
Western Blot
Figure 2: Western blot analysis using PGC-1alpha mAb against HEK293 (1) and PGC-1alpha-hIgGFc transfected HEK293 (2) cell lysate.
Figure 2: Western blot analysis using PGC-1alpha mAb against HEK293 (1) and PGC-1alpha-hIgGFc transfected HEK293 (2) cell lysate.
Elisa
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng);
Product Overview
Description

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. 

References (references)
References (references)1. Diabetes Res Clin Pract. 2009 Dec;86(3):168-72.
2.Cell Metab. 2009 Sep;10(3):189-98.