PEG10 Primary Antibody
PEG10: paternally expressed 10. This gene includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
2. FEBS Lett. 2008 Aug 6;582(18):2793-8.
![Figure 1: Western blot analysis using PEG10 mouse mAb against truncated Trx-PEG10 recombinant protein (1),truncated GST-PEG10 (aa1-120) recombinant protein (2) and full-length PEG10 (aa1-325)-hIgGFc transfected CHO-K1 cell lysate (3).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20295twb.jpg?v=1666698714)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human Placenta tissues using PEG10 mouse mAb](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20295ihc.jpg?v=1666698714)
![Figure 3: Confocal Immunofluorescence analysis of methanol-fixed HepG2 cells using PEG10 mouse mAb (green), showing cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20295icc.jpg?v=1666698714)