PAX6 Primary Antibody

Item Information
Catalog # Size/Concentration Price
30066 100μl $308.00
Specification
AliasesAN; AN2; MGDA; WAGR; D11S812E; MGC17209; PAX6
Product OrderP
Clone#1C8
Entrez GeneID5080
FormulationAscitic fluid containing 0.03% sodium azide.\
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human PAX6 expressed in E. Coli. \
MW46kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C.  Learn More
Species ReactivityHuman
Application
ELISA1/10000
FCM (Flow Cytometry)1/200 - 1/400
WB (Western Blot)1/500 - 1/2000
Sequence
1-223
Catalog
30066
$308.00
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Images

Western Blot

Cell Culture Products
Figure 1: Western blot analysis using PAX6 mAb against human PAX6 (AA: 1-223) recombinant protein. (Expected MW is 50 kDa)

Flow cytometric

Cell Culture Products
Figure 3: Flow cytometric analysis of 3T3-L1 cells using PAX6 mouse mAb (green) and negative control (purple).
Product Overview
Description Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.
References (references)
References (references) 1.Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2581-90.
2.J Biol Chem. 2009 Oct 2;284(40):27524-32.
3.J Biol Chem. 2010 Jan 22;285(4):2527-36.

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