PAR4 Primary Antibody
Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.
2. Exp Hematol. 2004 Jul;32(7):649-56.
3. Mol Cell Biol. 2005 Feb;25(3):1146-61.
4. Psychiatr Genet. 2006 Oct;16(5):193-6.
![Figure 1: Western blot analysis using PAR4 mouse mAb against full-length Trx-Par4 recombinant protein (1) and Hela cell lysate (2).](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20213rwb.jpg?v=1666698615)
![Figure 2: Immunohistochemical analysis of paraffin-embedded human brain (left) and breast carcinoma (right), showing cytoplasmic and membrane localization using PAR4 mouse mAb with DAB staining.](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20213ihc-1.jpg?v=1666698615)
![Figure 3: Immunohistochemical analysis of paraffin-embedded human Small Intestine tissues using PAR4 mouse mAb](https://cdn.shopify.com/s/files/1/0604/2661/7019/products/20213ihc-2.jpg?v=1666698615)