OCT4 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesOCT3; POU5F1
ProductOrderO
Clone#3A5
Entrez GenelD5460
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of OCT4 expressed in E. Coli.
MW39kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
WB (Western Blot)1/500 - 1/2000
Sequence
136-360 Cover 2 isoforms
Catalog#: 20384
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Images
Western Blot
Figure 1: Western blot analysis using OCT4 mouse mAb against PMA treated HepG2 cell lysate (1).
Figure 1: Western blot analysis using OCT4 mouse mAb against PMA treated HepG2 cell lysate (1).
Product Overview
Description

Members of Oct family of transcription factors specifically interact with Octamer motif ATGCAAAT, a regulatory element important for tissue- and cell-specific transcription as well as for transcription of a number of housekeeping genes. All of the members of the Oct family contain two highly conserved domains which are separated by 14-26 variable amino acids. These include the POU homeodomain and the POU-specific domain. Both are required for DNA binding and are involved in protein-protein interactions. Evidences indicate that regulation of Oct family transcription factors occurs at the level of phosphorylation. Oct4 is renowned as a transcription factor expressed by undifferentiated embryonic stem cells and embryonic germ cells.

References (references)
References (references)1. Stem Cells. 2009 Mar;27(3):543-9.
2. Genome Biol. 2008;9(12):R172.