NT5E Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliaseseN; NT5; CD73
ProductOrderN
Clone#1D7
Entrez GenelD4907
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of NT5E expressed in E. Coli.
MW70kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
Sequence
aa30-250
Catalog#: 20369
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Images
Immunohistochemical analysis
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), cholangiocarcinorna (B), lymph node (C) and esophagus (D) tissues using NT5E mouse mAb with DAB staining.
Figure 1: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), cholangiocarcinorna (B), lymph node (C) and esophagus (D) tissues using NT5E mouse mAb with DAB staining.
Product Overview
Description

5'-nucleotidase, ecto (NT5E), also known as CD73 (Cluster of Differentiation 73). Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase; EC 3.1.3.5) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. The enzyme consists of a dimer of 2 identical 70-kD subunits bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. The enzyme is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases (e.g., see MIM 102700, MIM 300300). Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.

References (references)
References (references)1. Oncol Rep. 2007 Jun;17(6):1341-6.
2. Neurochem Int. 2003 Dec;43(7):621-8.