NACC1 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesNAC1; BEND8; NAC-1; BTBD14B; FLJ37383; NACC1
ProductOrderN
Clone#6H2
Entrez GenelD112939
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of human NACC1 expressed in E. Coli.
MW58kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
165-438
Catalog#: 30137
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Images
Western Blot
Figure 1: Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1(AA: 165-438)-hIgGFc transfected HEK293 (2) cell lysate.
Figure 1: Western blot analysis using NACC1 mAb against HEK293 (1) and NACC1(AA: 165-438)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded mammary cancer tissues (left) and ovarian cancer tissues (right) using NACC1 mouse mAb with DAB staining.
Product Overview
Description

NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors . NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system . NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene . The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway . NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 . Tissue specificity: Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer .

References (references)
References (references)1. Neuroscience. 2002;110(3):421-9.
2. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12130-5.