MYL3 Primary Antibody

Item Information
Catalog #Size/ConcentrationPrice
Specification
AliasesCMH8; VLC1; MLC1V; MLC1SB
ProductOrderM
Clone#7C1
Entrez GenelD4634
FormulationAscitic fluid containing 0.03% sodium azide.
HostMouse
IsotypeIgG1
ImmunogenPurified recombinant fragment of MYL3 expressed in E. Coli.
MW22kDa
Shipping InformationThis product will ship in a box containing blue ice at a temperature of 4°C. Learn More
Species ReactivityHuman
Application
ELISA1/10000
IHC_P(Immunohistochemistry)1/200 - 1/1000
WB (Western Blot)1/500 - 1/2000
Sequence
2-195
Catalog#: 20343
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Images
Western Blot
Figure 1: Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fetal heart tissues lysate.
Figure 1: Western blot analysis using MYL3 (1) and MYL2 (2) mouse mAb against rat fetal heart tissues lysate.
Immunohistochemical analysis
Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal muscle (left) and cardiac muscle (right) using MYL3 mouse mAb with DAB staining.
Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal muscle (left) and cardiac muscle (right) using MYL3 mouse mAb with DAB staining.
Immunohistochemical analysis
Figure 3: Immunohistochemical analysis of paraffin-embedded human Heart tissues using MYL3 mouse mAb.
Figure 3: Immunohistochemical analysis of paraffin-embedded human Heart tissues using MYL3 mouse mAb.
Product Overview
Description

Myosins are a large superfamily of motor proteins that move along actin filaments, while hydrolyzing ATP. Myosin is the major component of thick muscle filaments, and is a long asymmetric molecule containing a globular head and a long tail. The molecule consists of two heavy chains and four light chains. Activation of smooth and cardiac muscle primarily involves pathways which increase calcium and myosin phosphorylation resulting in contraction. Myosin light chain phosphatase acts to regulate muscle contraction by dephosphorylating activated myosin light chain. MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Human myosin light chain has clinical application as a cardiac marker. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy.

References (references)
References (references)1. Xie B, et al. Biophys Chem. 2003 Oct 1;106(1):57-66.
2. Haase H, et al. FASEB J. 2006 May;20(7):865-73.